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The EBMT–ELN working group recommendations on the prophylaxis and treatment of GvHD: a change-control analysis

Bone Marrow Transplantation volume 52, pages 357–362 (2017)Cite this article

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Abstract

In 2013, recommendations for a standardized practice in the prophylaxis and treatment of GvHD were adopted and published by the European Society for Blood and Marrow Transplantation and the European LeukemiaNet. One year later, all 341 European Society for Blood and Marrow Transplantation centres performing allogeneic haematopoietic stem cell transplantation were contacted for a change-control analysis and asked to fill in a questionnaire; 111 centres (33%) responded. Of these, 83% had been aware of the recommendations. Paediatric centres (P=0.004), centres with shorter programme duration (P=0.049), not JACIE (the Joint Accreditation Committee of the International Society for Cellular Therapy and the European Society for Blood and Marrow Transplantation)-accredited centres (P=0.010) and centres from middle-income countries (P=0.033) were more likely to be unaware of the recommendations. Thirty-eight per cent of the centres regarded the recommendations as relevant guidelines affecting their policies, 61% as interesting information. Thirty per cent had decided to make changes in their institutional protocols based on the recommendations. More than 80% were willing to use the recommendations for a control arm in randomized studies. This survey shows that the published recommendations had some, though insufficient, impact on the strategies and methods of allogeneic haematopoietic stem cell transplantation applied by the centres. It also identified some of the weaknesses to be addressed when releasing recommendations in the future.

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Author information

Authors and Affiliations

  1. Comprehensive Cancer Center, Stem Cell Transplantation Unit, Helsinki University Hospital, Helsinki, Finland

    T Ruutu

  2. Hematology, Medical Faculty, University of Basel, Basel, Switzerland

    A Gratwohl

  3. Department of Hematology/Oncology and Hemostasiology, University of Leipzig, Leipzig, Germany

    D Niederwieser

  4. Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    T de Witte

  5. Department of Medical Statistics and Bioinformatics, EBMT Data Office Leiden, Leiden University Medical Center, Leiden, The Netherlands

    S van der Werf & A van Biezen

  6. Hopital Saint-Antoine, Paris, France

    M Mohty

  7. University Pierre & Marie Curie, Paris, France

    M Mohty

  8. INSERM UMRs 938, Paris, France

    M Mohty

  9. Department of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany

    N Kröger

  10. Hematology and Bone Marrow Transplant Unit, Ospedale Papa Giovanni XXIII, Bergamo, Italy

    A Rambaldi

  11. EBMT Executive Office & JACIE Office, Barcelona, Spain

    E McGrath

  12. Haematology Department, Institut Català d’Oncologia - Hospital Duran i Reynals, Barcelona, Spain

    A Sureda

  13. Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland

    G Basak

  14. Division of Haematology, Medical University of Graz, Graz, Austria

    H Greinix

  15. Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain

    R F Duarte

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  1. T Ruutu
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  2. A Gratwohl
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  4. T de Witte
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  5. S van der Werf
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  6. A van Biezen
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  8. N Kröger
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  10. E McGrath
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  14. R F Duarte
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Consortia

on behalf of the EBMT Complications and Quality of Life Working Party and the European LeukemiaNet Stem Cell Transplantation Work Package

Corresponding author

Correspondence to T Ruutu.

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The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies this paper on Bone Marrow Transplantation website

Supplementary information

Appendix

Appendix

Participating centres

Algeria, Centre Pierre et Marie Curie, Alger (703)

Austria, Medizinische Universitaet Wien, Vienna (227)

Austria, Elisabethinen-Hospital, Linz (594)

Belgium, Institut Jules Bordet, Brussels (215)

Belgium, Universitair Ziekenhuis Brussel, Brussels (234)

Croatia, University Hospital Center Zagreb (302)

Czech Republic, University Hospital Motol, Prague (452)

Czech Republic, University Hospital, Olomouc (574)

Czech Republic, Institute of Hematology and Blood Transfusion, Prague (656)

Czech Republic, Charles University Hospital, Pilsen (718)

Denmark, Rigshospitalet, Copenhagen (206)

Finland, Turku University Hospital, Turku (225)

Finland, Helsinki University Hospital, Helsinki (515)

France, CHU Bordeaux, Pessac (267)

France, CHRU de Lille - Hôpital HURIEZ, Lille (277)

France, Hôpital Robert Debre, Paris (631)

France, Gustave Roussy, Villejuif (666)

France, Centre Hospitalier Lyon Sud Pierre Benité, Lyon (671)

France, Hopital Saint-Antoine, Paris (213)

France, CHU Lapeyronie Montpellier (926)

Germany, Universitat Bonn (134)

Germany, Medical Center University of Tübingen (223)

Germany, University Hospital of Essen (259)

Germany, Hannover Medical School, Hannover (295)

Germany, Martin-Luther-Universität Halle-Wittenberg, Halle (338)

Germany, University Hospital Leipzig (389)

Germany, Heinrich Heine Universität, Dusseldorf (390)

Germany, University of Heidelberg (524)

Germany, University Hospital Eppendorf, Hamburg (614)

Germany, Klinikum Nürnberg (625)

Germany, University of Münster (680)

Germany, University of Saarland, Homburg (785)

Germany, University Hospital Erlangen (809)

Germany, University of Freiburg (810)

Greece, Patras University Medical School, Patras (281)

Greece, Evangelismos Hospital, Athens (622)

Greece, St.Savvas Oncology Hospital, Athens (751)

Israel, Chaim Sheba Medical Center, Tel-Hashomer (754)

Israel, Schneider Children's Medical Center of Israel, Petach-Tikva (755)

Italy, Institute G. Gaslini, Genova (274)

Italy, Centro Trapianti di Midollo Osseo - Ospedale San Gerardo, Monza (279)

Italy, Fondazione IRCCS Policlinico San Matteo, Pavia (286)

Italy, Ospedale S. Camillo-Forlanini, Rome (287)

Italy, Hospital San Maurizio, Bolzano (299)

Italy, Ospedale di Careggi, Florence (304)

Italy, Universita Cattolica S. Cuore – Gemelli, Rome (307)

Italy, Istituto Clinico Humanitas, Rozzano (354)

Italy, Ospedale V. Cervello, Palermo (392)

Italy, Centro Unico Regionate Trapianti Cellule Staminali e Terapie Cellulari, Reggio_Calabria (587)

Italy, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo (658)

Italy, Ospedale La Maddalena - Dpt. Oncologico, Palermo (692)

Italy, Azienda Ospedaliero Universitaria di Udine (705)

Italy, Azienda Ospedali Riuniti di Ancona (788)

Italy, Ospedale A. Businco Cagliari (791)

Italy, Azienda Policlinico Vittorio Emanuele, Catania (792)

Italy, Ospedale San Raffaele s.r.l., Milano (813)

Italy, H SS. Antonio e Biagio, Alessandria (825)

Lebanon, American University of Beirut Medical Center, Beirut (369)

Lithuania, Children's Hospital, Vilnius University Hospital Santariskiu Klinikos, Vilnius (508)

Lithuania, Vilnius University Hospital Santariskiu Klinikos, Vilnius (644)

Netherlands, Leiden University Medical Center, Leiden (203)

Norway, Haukeland University Hospital, Bergen (197)

Poland, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice (428)

Poland, University Children's Hospital in Krakow (507)

Poland, Lower Silesian Center for Cellular Transplantations, Wroclaw (538)

Poland, Institute of Hematology and Transfusion Medicine, Warsaw (693)

Poland, University Hospital, Collegium Medicum UMK, Bydgoszcz (764)

Poland, Central Clinical Hospital, Medical University of Warsaw (954)

Russia, National Research Center for Hematology, Moscow (930)

Saudi Arabia, King Faisal Specialist Hospital & Research Centre, Riyadh (397)

Serbia, Mother and Child Health Care Institute of Serbia 'Dr Vukan Cupic', Belgrade (358)

Spain, Hospital Clinic Barcelona (214)

Spain, Hospital Reina Sofia, Cordoba (238)

Spain, Hospital Clínico Universitario, Valencia (282)

Spain, Fundación Jiménez Díaz, Madrid (309)

Spain, Hospital Universitario Virgen de la Arrixaca, Murcia (323)

Spain, Complexo Hospitalario Universitario de Vigo (421)

Spain, Hospital de Gran Canaria 'Dr Negrin', Las Palmas (537)

Spain, ICO – Hospital Universitari Germans Trias i Pujol, Barcelona (613)

Spain, Hospital Clínico de Salamanca (727)

Spain, Clinica Puerta de Hierro, Madrid (728)

Spain, Niño Jesus Children's Hospital, Madrid (732)

Spain, ICO – Hospital Duran i Reynals, Barcelona (759)

Sweden, Karolinska University Hospital, Stockholm (212)

Sweden, Akademiska Sjukhuset, Uppsala (266)

Sweden, Skanes University Hospital, Lund (283)

Sweden, Sahlgrenska University Hospital, Goteborg (289)

Sweden, Umea University Hospital, Umea (731)

Sweden, University Hospital Linköping (740)

Switzerland, University Hospital Basel (202)

Tunisia, Centre National de Greffe de Moelle, Tunis (183)

Turkey, Hacettepe University, Ankara (168)

Turkey, Gazi University School of Medicine, Ankara (182)

Turkey, Hacettepe University Children's Hospital, Ankara (399)

Turkey, Ankara Bayindir Hospital (412)

Turkey, Erciyes University Hospital, Kayseri (627)

Turkey, Medical Park Antalya Hospital (911)

Turkey, Medical Park Goztepe Hospital, Istanbul (929)

Turkey, Florence Nightingale Sisli Hospital, Istanbul (994)

United Kingdom, Hammersmith Hospital, London (205)

United Kingdom, University College London Hospital, London (224)

United Kingdom, Beatson West of Scotland Cancer Centre, Glasgow (244)

United Kingdom, University Hospital Birmingham NHS Trust (387)

United Kingdom, Manchester Royal Infirmary (601)

United Kingdom, Southampton General Hospital (704)

United Kingdom, Nottingham University Hospital (717)

United Kingdom, St. Bartholomew's and The Royal London NHS Trust, London (768)

United Kingdom, Christie NHS Trust Hospital, Manchester (780)

United Kingdom, Plymouth Hospitals NHS Trust, Plymouth (823)

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Ruutu, T., Gratwohl, A., Niederwieser, D. et al. The EBMT–ELN working group recommendations on the prophylaxis and treatment of GvHD: a change-control analysis. Bone Marrow Transplant 52, 357–362 (2017). https://doi.org/10.1038/bmt.2016.298

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  • DOI: https://doi.org/10.1038/bmt.2016.298

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