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  • Clinical Oncology/Epidemiology
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Clinical Oncology/Epidemiology

Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix

British Journal of Cancer volume 66, pages 1150–1154 (1992)Cite this article

Abstract

We have investigated the oestrogen receptor (ER) status of 20 cervical adenocarcinomas by immunocytochemistry for ER protein and non-isotopic in situ hybridisation for ER mRNA. Both methods, which are applicable to paraffin sections, were developed and validated in breast carcinomas with known ER content. Six cervical adenocarcinomas contained immunocytochemically demonstrable ER protein; all contained ER mRNA, but staining was less intense in poorly differentiated areas of four tumours. This disparity between protein and mRNA detection needs further investigation as does the possibility that oestrogens may play a role in the pathogenesis of cervical adenocarcinoma.

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Authors and Affiliations

  1. Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, UK

    SM Ismail

Authors
  1. SM Ismail
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  2. GA Thomas
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  3. FA Ghandour
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  4. HG Davies
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  5. R Attanoos
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  6. ED Williams
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Ismail, S., Thomas, G., Ghandour, F. et al. Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix. Br J Cancer 66, 1150–1154 (1992). https://doi.org/10.1038/bjc.1992.425

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  • DOI: https://doi.org/10.1038/bjc.1992.425

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