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Genetic linkage of Werner's syndrome to five markers on chromosome 8

Nature volume 355, pages 735–738 (1992)Cite this article

Abstract

WERNER'S syndrome (WS) is a rare autosomal recessive disease in which the affected individuals display symptoms of premature ageing1–3. The substantial phenotypic overlap between WS and normal ageing indicates that these two conditions may have pathogenetic mechanisms in common3–5. The WS mutation has pleiotropic effects, and patients and their cells show many differences compared with normals5. Despite extensive study of the clinical and biochemical features of this disorder, the primary genetic defect remains unknown. We have undertaken a genetic linkage study in an effort to identify the locus of the primary defect6. Here we report close genetic linkage of the WS mutation to a group of markers on chromosome 8.

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Author information

Authors and Affiliations

  1. Departments of Molecular Biology and Genentech Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Mark Rubenstein & Dennis Drayna

  2. Department of Rheumatology, Tokyo Metropolitan Otsuka Hospital, 2-8-1 Minami-Otsuka, Tokyo, 170, Japan

    Makoto Goto

  3. Marshfield Foundation for Medical Research, 1000 N. Oak Street, Marshfield, Wisconsin, 54449, USA

    James Weber

  4. Scientific Computing, Genentech Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Kathryn Woods

Authors
  1. Makoto Goto
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  2. Mark Rubenstein
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  3. James Weber
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  4. Kathryn Woods
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  5. Dennis Drayna
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Goto, M., Rubenstein, M., Weber, J. et al. Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature 355, 735–738 (1992). https://doi.org/10.1038/355735a0

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