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Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

Abstract

Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.

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Gian Luca Rampioni Vinciguerra, Marina Capece, … Carlo M. Croce

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Binétruy, B., Smeal, T. & Karin, M. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351, 122–127 (1991). https://doi.org/10.1038/351122a0

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