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Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs

Nature volume 348, pages 76–80 (1990)Cite this article

Abstract

WE have cloned and characterized a mitogen-inducible gene isolated from human T cells that predicts a protein of 968 amino acids. The amino-terminal domain has regions homologous to the oncogene rel and to the developmentally important gene dorsal of Drosophila. The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans, as well as in the putative human oncogene bcl-3 and in the ankyrin protein. A truncated form of the product of this gene translated in vitro is a DNA-binding protein which interacts specifically with the KB binding site found in many inducible genes, including the enhancer in human immunodeficiency virus. This gene is yet another in a growing list of important regulatory molecules whose expression is transcrip-tionally induced upon cellular activation.

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Authors and Affiliations

  1. Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, 20892, USA

    Vincent Bours, Juanita Villalobos, Parris R. Burd & Ulrich Siebenlist

  2. Laboratory of Pathology, National Cancer Institute, The National Institutes of Health, Bethesda, Maryland, 20892, USA

    Kathleen Kelly

Authors
  1. Vincent Bours
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  2. Juanita Villalobos
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  3. Parris R. Burd
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  4. Kathleen Kelly
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  5. Ulrich Siebenlist
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Bours, V., Villalobos, J., Burd, P. et al. Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs. Nature 348, 76–80 (1990). https://doi.org/10.1038/348076a0

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