Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6

Nature volume 323, pages 540–543 (1986)Cite this article

Abstract

Thymocyte antigens CD1 [Thy,gp45,12] are thought to be the human counterparts of mouse thymus leukaemia (TL) antigens1,2. Serological and biochemical analyses indicate that at least three subsets exist3–6, the first of which (HTA 1/T6) was initially identified by the monoclonal antibody NA1/34 (refs 7,8). Like TL, CD1 are expressed on cortical thymocytes as well as on some lymphoid neoplasias, and resemble in structure major histocompatabiliry complex (MHC) class I antigens. However HTA 1/T6 is loosely associated with β2-microglobulin9–10 and is also found linked by a disulphide bridge to CD8 (T8)11,12. A molecular genetic approach is needed to investigate the CD1 system, to clarify its relationship to TL antigens and to understand its regulation. We report the isolation of complementary DNA (cDNA) clones encoding a CD1 antigen. These clones reveal a novel family of genes which are MHC-related but are neither equivalent to mouse TL antigens nor linked to the MHC.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bernard, A., Boumsell, L. & Hill, C. Joint Report of the First International Workshop on Human Leukocyte Differentiation Antigens by the Investigators of the Participating Laboratories in Leukocyte Typing (eds A. Bernard, L. Boumsell, J. Dausset & C. Milstein) (Springer, Berlin, 1984).

    Google Scholar 

  2. Boyse, E. A. Cell 38, 1–2 (1984).

    CAS  PubMed  Google Scholar 

  3. Knowles, R. W. in Leucocyte Typing 2 (eds Reinherz, E. L., Haynes, B. J., Bernstein, I. D. & Nadler, L. M.) 259–264 (Springer, New York, 1985).

    Google Scholar 

  4. Olive, D., Dubreuil, P. & Mawas, C. Immunogenetics 20, 253–264 (1984).

    CAS  PubMed  Google Scholar 

  5. Kahn-Perles, B., Wietzerbin, J., Caillol, D. H. & Lemonnier, F. J. Immun. 134, 1759–1765 (1985).

    CAS  PubMed  Google Scholar 

  6. Amiot, M. et al. J. Immun. 136, 1752–1758 (1986).

    CAS  PubMed  Google Scholar 

  7. McMichael, A. J. et al. Eur. J. Immun. 9, 205–210 (1979).

    CAS  Google Scholar 

  8. Reinherz, E. L. & Schlossman, S. F. Cell 19, 821–827 (1980).

    CAS  PubMed  Google Scholar 

  9. Ziegler, A. & Milstein, C. Nature 279, 243–244 (1979).

    ADS  CAS  PubMed  Google Scholar 

  10. Kefford, R. K., Calabi, F., Fearnley, I., Burrone, O. R. & Milstein, C. Nature 308, 641–642 (1984).

    ADS  CAS  PubMed  Google Scholar 

  11. Ledbetter, J. A., Tsu, T. T. & Clark, E. A. J. Immun. 134, 4250–4254 (1985).

    CAS  PubMed  Google Scholar 

  12. Snow, P. M., van de Rijn, M. & Terhorst, C. Eur. J. Immun. 15, 529–532 (1985).

    CAS  Google Scholar 

  13. Burrone, O. R., Calabi, F., Kefford, R. F. & Milstein, C. EMBO J. 2, 1591–1595 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Edge, A. S. B., Faltynek, C. R., Hof, L., Reichert, L. E. Jr & Weber, P. Analyt. Biochem. 118, 131–137 (1981).

    CAS  PubMed  Google Scholar 

  15. Palmiter, R. D. Biochemistry 13, 3606–3615 (1974).

    CAS  PubMed  Google Scholar 

  16. Messing, J. Meth. Enzym. 101, 20–78 (1983).

    CAS  PubMed  Google Scholar 

  17. Miller, J. S., Paterson, B. M., Ricciardi, R. P., Cohen, L. & Roberts, B. E. Meth. Enzym. 101, 650–674 (1983).

    CAS  PubMed  Google Scholar 

  18. Huynh, T. V., Young, R. A. & Davis, R. W. in DNA cloning I (ed. Glover, D. M.) 49–78 (Cambridge University Press, 1985).

    Google Scholar 

  19. Sood, A. K., Pereira, D. & Weissman, S. Proc. natn. Acad. Sci. U.S.A. 78, 616–620 (1981).

    ADS  CAS  Google Scholar 

  20. Minowada, J. J. Cancer Res. clin. Oncol. 101, 91 (1980).

    Google Scholar 

  21. Minowada, J., Sagawa, K., Trowbridge, I. S., Kung, P. D. & Goldstein, G. in Malignant Lymphomas: Etiology, Immunology, Pathology and Treatment (eds Kaplan, H. & Rosen-berg, S.) 53–74 (Academic, New York, 1982).

    Google Scholar 

  22. Bernheim, A., Berger, R. & Lenoir, G. Cancer Genet. Cytogenet. 3, 307–315 (1981).

    CAS  PubMed  Google Scholar 

  23. Trucco, M. M., Garotta, G., Stocker, J. W. & Ceppellini, R. Immun. Rev. 47, 219–252 (1979).

    CAS  PubMed  Google Scholar 

  24. Calabi, F. & Neuberger, M. S. EMBO J. 4, 667–674 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Neuberger, M. S. EMBO J. 2, 1373–1378 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular cloning. A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  27. Bankier, A. T., Weston, K. M. & Barrell, B. G. Meth. Enzym. (in the press).

  28. Staden, R. Nucleic Acids Res. 14, 217–231 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Svasti, J. & Milstein, C. Biochem. J. 126, 837–850 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Williams, A. F., Barclay, A. N., Clark, M. J. & Gagnon, J. in Gene Expression During Normal and Malignant Differentiation (eds Andersson, L. C., Gahmberg, C. G. & Ekblom, P.) 125 (Academic, London, 1985).

    Google Scholar 

  31. van Agthoven, A. & Terhorst, C. J. Immun. 128, 426–432 (1982).

    CAS  PubMed  Google Scholar 

  32. Wilbur, W. J. & Lipman, D. J. Proc. natn. Acad. Sci. U.S.A. 80, 726–730 (1982).

    ADS  Google Scholar 

  33. Klein, J. & Figueroa, F. Immun. Today 7, 41–44 (1985).

    Google Scholar 

  34. Klein, J. & Figueroa, F. Immun. Today 7, 78–81 (1985).

    Google Scholar 

  35. Wilkinson, J. M., Tycocinski, M. L., Coligan, J. E., Kimball, E. S. & Kindt, T. J. Molec. Immun. 19, 1441–1451 (1982).

    CAS  PubMed  Google Scholar 

  36. Potter, T. A., Boyer, C., Schmitt Verhulst, A., Golstein, P. & Rajan, T. V. J. exp. Med. 160, 317–322 (1984).

    CAS  PubMed  Google Scholar 

  37. Yokoyama, K. & Nathenson, S. G. J. Immun. 130, 1419–1425 (1983).

    CAS  PubMed  Google Scholar 

  38. Hyman, R. & Stallings, V. Immunogenetics 6, 447–458 (1978).

    Google Scholar 

  39. Martin, L. H., Calabi, F. & Milstein, C. Proc. natn. Acad. Sci. U.S.A. (in the press).

  40. Bernard, O., Cory, S., Gerondakis, S., Webb, E. & Adams, J. M. EMBO J. 2, 2375–2383 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Parnes, J. R., Robinson, R. R. & Seidman, J. G. Nature 302, 449–452 (1983).

    ADS  CAS  PubMed  Google Scholar 

  42. Blattner, F. R. & Tucker, P. W. Nature 307, 417–422 (1984).

    ADS  CAS  PubMed  Google Scholar 

  43. Rogers, J. H. EMBO J. 4, 749–753 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    F. Calabi & C. Milstein

Authors
  1. F. Calabi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Milstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Calabi, F., Milstein, C. A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. Nature 323, 540–543 (1986). https://doi.org/10.1038/323540a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/323540a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing