Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

Nature volume 308, pages 153–158 (1984)Cite this article

Abstract

Comparison of the sequence of a cloned T cell-specific cDNA with those of cross-reacting cloned cDNAs isolated from a thymocyte library indicates the presence of variable, constant and joining regions remarkably similar in size and sequence to those encoding immunoglobulin proteins. Together with the evidence for somatic gene rearrangements reported in the accompanying paper, this strongly suggests that the TM86 cDNA clone encodes one chain of the T-cell receptor for antigen.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hedrick, S. M., Cohen, D. I., Nielson, E. A. & Davis, M. M. Nature 308, 149–153 (1984).

    Article  ADS  CAS  Google Scholar 

  2. Kabat, E. A., Wu, T. T., Bilofsky, H., Reid-Miller, M. & Perry, H. Sequences of Immunological Interest (US Dept of Health and Human Services, Washington, DC, 1983).

    Google Scholar 

  3. Dreyer, W. T. & Bennett, J. C. Proc. natn. Acad. Sci. U.S.A. 54, 864–868 (1965).

    Article  ADS  CAS  Google Scholar 

  4. Brack, C., Hirama, M., Lenhard-Schuller, R. & Tonegawa, S. Cell 15, 1–14 (1978).

    Article  CAS  Google Scholar 

  5. Seidman, J. G. & Leder, P. Nature 276, 790–795 (1978).

    Article  ADS  CAS  Google Scholar 

  6. Early, P., Huang, H., Davis, M., Calame, K. & Hood, L. Cell 19, 981–992 (1980).

    Article  CAS  Google Scholar 

  7. Sakano, H. et al. Nature 277, 627–635 (1979).

    Article  ADS  CAS  Google Scholar 

  8. Maniatis, T., Fritsch, E. & Sambrook, J. in Molecular cloning (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  9. Viera, J. & Messing, J. Gene 19, 259–268 (1982).

    Article  Google Scholar 

  10. Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).

    Article  CAS  Google Scholar 

  11. Wilbur, N. J. & Lipman, D. J. Proc. natn. Acad. Sci. U.S.A. 80, 726–730 (1983).

    Article  ADS  CAS  Google Scholar 

  12. Auffray, C., Korman, A. J., Roux-Desseto, M., Bono, R. & Strominger, J. Proc. natn. Acad. Sci. U.S.A. 79, 6337–6341 (1982).

    Article  ADS  CAS  Google Scholar 

  13. Estess, P., Nisonoff, A. & Capra, J. D. Molec. Immun. 16, 1111–1118 (1979).

    Article  CAS  Google Scholar 

  14. Hood, L., McKean, D., Farnsworth, V. & Potter, M. Biochemistry 12, 741–749 (1973).

    Article  CAS  Google Scholar 

  15. Appella, E. Proc. natn. Acad. Sci. U.S.A. 68, 590–594 (1971).

    Article  ADS  CAS  Google Scholar 

  16. Eichmann, K. & Rajewsky, K. Eur. J. Immun. 5, 661–666 (1975).

    Article  CAS  Google Scholar 

  17. Binz, H. & Wigzell, H. J. exp. Med. 142, 197–211 (1975).

    Article  CAS  Google Scholar 

  18. Augustin, A. A., Julius, M. H., Cosenza, H. & Matsunaga, T. in Regulatory T Lymphocytes (eds Pernis, B. & Vogel, H. J.) (Academic, New York, 1980).

    Google Scholar 

  19. Kronenberg, M., Davis, M. M., Early, P. W., Hood, L. E. & Watson, J. D. J. exp. Med. 152, 1745–1761 (1980).

    Article  CAS  Google Scholar 

  20. Nakanishi, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6984–6988 (1982).

    Article  ADS  CAS  Google Scholar 

  21. Kurosawa, Y. H. et al. Nature 290, 565–570 (1981).

    Article  ADS  CAS  Google Scholar 

  22. Kronenberg, M. et al. J. exp. Med. 158, 210–227 (1983).

    Article  CAS  Google Scholar 

  23. Acuto, O. et al. Cell 34, 717–726 (1983).

    Article  CAS  Google Scholar 

  24. McIntyre, B. W. & Allison, J. P. Cell 34, 739–746 (1983).

    Article  CAS  Google Scholar 

  25. Kappler, J., Kubo, R., Haskins, K., White, J. & Marrack, P. Cell 34, 727–737 (1983).

    Article  CAS  Google Scholar 

  26. Kabat, E. A., Wu, T. T. & Bilofsky, H. Proc. natn. Acad. Sci. U.S.A. 75, 2429–2433 (1978).

    Article  ADS  CAS  Google Scholar 

  27. Sakano, H., Kurosawa, Y., Weigert, M. & Tonegawa, S. Nature 290, 562–579 (1981).

    Article  ADS  CAS  Google Scholar 

  28. Kurosawa, Y. & Tonegawa, S. J. exp. Med. 155, 201–218 (1982).

    Article  CAS  Google Scholar 

  29. Kyte, J. & Doolittle, R. F. J. molec. Biol. 157, 105–132 (1982).

    Article  CAS  Google Scholar 

  30. Larhammar, D. et al. Cell 30, 153–161 (1982).

    Article  CAS  Google Scholar 

  31. Wagh, P. V. & Bahl, O. P. Crit. Rev. Biochem. 11, 307–377 (1981).

    Article  Google Scholar 

  32. Benoist, C. O. et al. Cell 34, 169–177 (1983).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Stephen M. Hedrick & Mark M. Davis

    Present address: Department of Biology, University of California at San Diego, La Jolla, California, 92093, USA

Authors and Affiliations

  1. Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Stephen M. Hedrick, Ellen A. Nielsen, David I. Cohen & Mark M. Davis

  2. Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California, 94305, USA

    Joshua Kavaler, David I. Cohen & Mark M. Davis

Authors
  1. Stephen M. Hedrick
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ellen A. Nielsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joshua Kavaler
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. David I. Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mark M. Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hedrick, S., Nielsen, E., Kavaler, J. et al. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature 308, 153–158 (1984). https://doi.org/10.1038/308153a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/308153a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing