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Protein phosphorylation in the brain

Nature volume 305, pages 583–588 (1983)Cite this article

Abstract

Protein phosphorylation represents an approach, sometimes the only approach available, to study the molecular basis for a wide variety of neurophysiological phenomena. The injection of protein kinases or protein kinase inhibitors into neurones has provided direct evidence that activation of protein kinases has an obligatory role in the mechanisms by which numerous extracellular signals produce specific physiological responses in neurones. A diversity of substrate proteins for the kinases have already been found. In several instances, the identity and functional role of these substrate proteins have been established.

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  1. Eric J. Nestler

    Present address: McLean Hospital, Belmont, Massachusetts, 02178, USA

  2. Paul Greengard

    Present address: The Rockefeller University, New York, New York, 10021, USA

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  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Eric J. Nestler & Paul Greengard

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Nestler, E., Greengard, P. Protein phosphorylation in the brain. Nature 305, 583–588 (1983). https://doi.org/10.1038/305583a0

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