Abstract
Recently, there has been intense interest in the possibility that peptides might function as neurotransmitters1,2. Despite much progress, there remains no clear-cut example in which the production of a chemically characterized peptide may be ascribed to individual identifiable neurones of proven physiological role/Invertebrate systems have proved to be particularly valuable for the study of identified neurones, including those producing peptides3,4. We have now identified a neurone in ganglia of Helix that is associated with a peptide of the Phe-Met-Arg-Phe-NH2 (FMRFamide) group, and which influences tentacle contraction. This system offers for the first time the capacity to study peptidergic transmission in a system in which both the cell soma and the postsynaptic target may be readily and reproducibly identified.
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Cottrell, G., Schot, L. & Dockray, G. Identification and probable role of a single neurone containing the neuropeptide Helix FMRFamide. Nature 304, 638–640 (1983). https://doi.org/10.1038/304638a0
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DOI: https://doi.org/10.1038/304638a0
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