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Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster

Nature volume 304, pages 412–417 (1983)Cite this article

Abstract

The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of the 43 polymorphisms results in an amino acid change, the one responsible for the two electrophoretic variants (fast, Adh-f, and slow, Adh-s) found in nearly all natural populations. The implication is that most amino acid changes in Adh would be selectively deleterious.

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  1. Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts, 02138, USA

    Martin Kreitman

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  1. Martin Kreitman
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Kreitman, M. Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster. Nature 304, 412–417 (1983). https://doi.org/10.1038/304412a0

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