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Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen

Nature volume 302, pages 490–495 (1983)Cite this article

Abstract

Potential live vaccines against hepatitis B virus have been produced. The coding sequence for hepatitis B virus surface antigen (HBsAg) has been inserted into the vaccinia virus genome under control of vaccinia virus early promoters. Cells infected with these vaccinia virus recombinants synthesize and excrete HBsAg and vaccinated rabbits rapidly produce antibodies to HBsAg.

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Authors and Affiliations

  1. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Geoffrey L. Smith, Michael Mackett & Bernard Moss

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  1. Geoffrey L. Smith
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  2. Michael Mackett
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  3. Bernard Moss
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Smith, G., Mackett, M. & Moss, B. Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen. Nature 302, 490–495 (1983). https://doi.org/10.1038/302490a0

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