Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Recombination between dispersed serine tRNA genes in Schizosaccharomyces pombe

Nature volume 300, pages 225–231 (1982)Cite this article

Abstract

During meiosis in fission yeast, transfer of genetic information occurs between tRNA genes of related sequence even when they are located on different chromosomes. This process of intergenic conversion has been analysed with the help of nonsense suppressors derived from three unlinked serine tRNA genes. In their wild-type form two of the genes code for tRNASerUCA, the third for tRNASerUCG. We demonstrate the transfer of anticodon and adjacent intron sequences between two tRNA genes coding for different serine isoacceptors.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Smith, G. P. Cold Spring Harb. Symp. quant. Biol. 38, 507–513 (1974).

    Article  CAS  Google Scholar 

  2. Petes, T. D. Cell 19, 765–774 (1980).

    Article  CAS  Google Scholar 

  3. Szostak, J. W. & Wu, R. Nature 284, 426–430 (1980).

    Article  ADS  CAS  Google Scholar 

  4. Anderson, P. & Roth, J. Proc. natn. Acad. Sci. U.S.A. 78, 3113–3117 (1981).

    Article  ADS  CAS  Google Scholar 

  5. Zimmer, E. A., Martin, S. L., Beverley, S. M., Kan, Y. W. & Wilson, A. C. Proc. natn. Acad. Sci. U.S.A 77, 2158–2162 (1980).

    Article  ADS  CAS  Google Scholar 

  6. Shen, S., Slightom, J. L. & Smithies, O. Cell 26, 191–203 (1981).

    Article  CAS  Google Scholar 

  7. Siebenlist, U., Ravetch, J. V., Korsmeyer, S., Waldmann, T. & Leder, P. Nature 294, 631–635 (1981).

    Article  ADS  CAS  Google Scholar 

  8. Arnheim, N., Krystal, M., Schmickel, R., Wilson, G., Ryder, O. & Zimmer, E. Proc. natn. Acad. Sci. U.S.A. 77, 7323–7327 (1980).

    Article  ADS  CAS  Google Scholar 

  9. Coen, E. S., Thoday, J. M. & Dover, G. Nature 295, 564–568 (1982).

    Article  ADS  CAS  Google Scholar 

  10. Brown, S. D. M. & Dover, G. J. molec. Biol. 150, 441–466 (1981).

    Article  CAS  Google Scholar 

  11. Selker, E. U. et al. Cell 24, 819–828 (1981).

    Article  CAS  Google Scholar 

  12. Edelman, G. M. & Gally, J. A. in The Neurosciences: Second Study Program (ed. Schmitt, F. O.) 962–972 (Rockefeller University Press, New York, 1970).

    Google Scholar 

  13. Birky, C. W. Jr & Skavaril, R. V. Genet. Res. 27, 249–265 (1976).

    Article  CAS  Google Scholar 

  14. Meselson, M. S. & Radding, C. M. Proc. natn. Acad. Sci. U.S.A. 72, 358–361 (1975).

    Article  ADS  CAS  Google Scholar 

  15. Scherer, S. & Davis, R. W. Science 209, 1380–1384 (1980).

    Article  ADS  CAS  Google Scholar 

  16. Klein, H. L. & Petes, T. D. Nature 289, 144–148 (1981).

    Article  ADS  CAS  Google Scholar 

  17. Jackson, J. A. & Fink, G. R. Nature 292, 306–311 (1981).

    Article  ADS  CAS  Google Scholar 

  18. Ernst, J. F., Stewart, J. W. & Sherman, F. J. molec. Biol. (in the press).

  19. Munz, P. & Leupold, U. in Molecular Genetics in Yeast, Alfred Benzon Symposium 16 (eds von Wettstein, D., Friis, J., Kielland-Brandt, M. & Stenderup, A.) 264–275 (Munksgaard, Copenhagen, 1981).

    Google Scholar 

  20. Munz, P., Leupold, U., Agris, P. & Kohli, J. Nature 294, 187–188 (1981).

    Article  ADS  CAS  Google Scholar 

  21. Hottinger, H. et al. Molec. gen. Genet. (in the press).

  22. Kohli, J. et al. in Transfer RNA: Biological Aspects (eds Söll, D., Abelson, J. N. & Schimmel, P. R.) 407–419 (Cold Spring Harbor Laboratory, New York, 1980).

    Google Scholar 

  23. Mao, J., Schmidt, O. & Söll, D. Cell 21, 509–516 (1980).

    Article  CAS  Google Scholar 

  24. Hofer, F., Hollenstein, H., Janner, F., Minet, M., Thuriaux, P. & Leupold, U. Curr. Genet. 1, 45–61 (1979).

    Article  CAS  Google Scholar 

  25. Egel, R., Kohli, J., Thuriaux, P. & Wolf, K. A. Rev. Genet. 14, 77–108 (1980).

    Article  CAS  Google Scholar 

  26. Kohli, J., Hottinger, H., Munz, P., Strauss, A. & Thuriaux, P. Genetics 87, 471–489 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  28. Rafalski, A., Kohli, J., Agris, P. & Söll, D. Nucleic Acids Res. 6, 2683–2695 (1979).

    Article  CAS  Google Scholar 

  29. Wetzel, R., Kohli, J., Altruda, F. & Söll, D. Molec. gen. Genet. 172, 221–228 (1979).

    Article  CAS  Google Scholar 

  30. DasGupta, C. & Radding, C. Proc. natn. Acad. Sci. U.S.A. 79, 762–766 (1982).

    Article  ADS  CAS  Google Scholar 

  31. Cedergren, R. J., Sankoff, D., LaRue, B. & Grosjean, H. CRC crit. Rev. Biochem. 11, 35–104 (1981).

    Article  CAS  Google Scholar 

  32. Roberts, T. M., Swanberg, S. L., Poteete, A., Riedel, G. & Backman, K. Gene 12, 123–127 (1980).

    Article  CAS  Google Scholar 

  33. Messing, J., Gronenborn, B., Müller-Hill, B. & Hofschneider, P. H. Proc. natn. Acad. Sci. U.S.A. 74, 3642–3646 (1977).

    Article  ADS  CAS  Google Scholar 

  34. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of General Microbiology, University of Bern, Baltzer-Strasse 4, CH-3012, Bern, Switzerland

    Peter Munz, Hanspeter Amstutz, Jürg Kohli & Urs Leupold

Authors
  1. Peter Munz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hanspeter Amstutz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jürg Kohli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Urs Leupold
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Munz, P., Amstutz, H., Kohli, J. et al. Recombination between dispersed serine tRNA genes in Schizosaccharomyces pombe. Nature 300, 225–231 (1982). https://doi.org/10.1038/300225a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/300225a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing