Abstract
Actin heterogeneity is well known: within one vertebrate species up to six forms of actin, differing in isoelectric point, amino acid composition and antigenic sites have been described and their synthesis shown to be tissue specific1–8. In Drosophila melanogaster actin genes have been located at six distinct sites on the chromosomes9,10 and three forms of actin (synthesized and/or accumulated in different amounts in different tissues11–14) have been distinguished electrophoretically. In view of the obvious importance of actin in muscle, it was of interest to search in Drosophila for abnormalities of actin in flightless mutants which primarily affect fibrillar flight muscles, such as raised (rsd)14–20. Here we report that the actin pattern in two types of adult skeletal muscles is differently affected by the rsd mutation. Since rsd is located on the right arm of the third chromosome25, which is not the known position of the structural genes of actin9,10, we conclude that rsd is a regulatory gene.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Whalen, R. G., Butler-Browne, G. S. & Gros, F. Proc. natn. Acad. Sci. U.S.A. 73, 2018–2022 (1976).
Garreis, J. I. & Gibson, W. Cell 9, 793–805 (1976).
Zechel, K. & Weber, K. Eur. J. Biochem. 89, 105–112 (1978).
Elzinga, M. & Lu, R. C. in Contractile Systems in Non-Muscle Tissue (eds Perry, S. V., Margreth, A. & Adelstein, R. S.) 29–37 (North-Holland, Amsterdam, 1976).
Vandekerckhove, J. & Weber, K. Differentiation 14, 123–133 (1979).
Vandekerckhove, J. & Weber, K. FEBS Lett. 102, 219–222 (1979).
Morgan, J. L., Holladay, C. R. & Spooner, B. S. Proc. natn. Acad. Sci. U.S.A. 77, 2069–2073 (1980).
Vandekerckhove, J. & Weber, K. J. molec. Biol 126, 783–802 (1978).
Fyrberg, E. A., Kindle, K. L. & Davidson, N. Cell 19, 365–378 (1980).
Tobin, S. L., Zulauf, E., Sanchez, F., Craig, E. A. & McCarthy, B. J. Cell 19, 121–131 (1980).
Horovitch, S. J., Storti, R. V., Rich, A. & Pardue, M. L. J. Cell Biol 82, 86–92 (1979).
Fyrberg, E. A. & Donady, J. J. Devi Biol 68, 487–502 (1979).
Storti, R. V., Horovitch, S. J., Scott, M. P., Rich, A. & Pardue, M. L. Cell 13, 589–598 (1978).
Berger, E. & Cox, G. J. Cell Biol 81, 680–683 (1979).
Lang, A. B., Wyss, C. & Eppenberger, H. M. J. Muscle Res. Cell Motility 1, 147–161 (1980).
Lang, A. B., Wyss, C. & Eppenberger, H. M. J. Muscle Res. Cell Motility 1, 478 (1980).
Hotta, Y. & Benzer, S. Nature 240, 527–535 (1972).
Benzer, S. Scient. Am. 229, 24–37 (1973).
Deak, I. I. J. Embryol. exp. Morph. 40, 35–63 (1977).
Koana, T. & Hotta, Y. J. Embryol. exp. Morph. 45, 123–143 (1978).
Wyss, C. Somat. Cell Genet. 5, 23–28 (1979).
O'Farrell, P. H. J. biol Chem. 250, 4007–4021 (1975).
Bonner, W. H. & Laskey, R. A. Eur. J. Biochem. 46, 83–88 (1974).
Bullard, B., Bell, J., Craig, R. & Leonard, K. J. Muscle Res. Cell Motility 1, 194–195 (1980).
Lindsley, D. L. & Grell, E. H. (eds) Genetic Variations of Drosophila melanogaster (Carnegie Institution, Washington DC, 1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lang, A., Wyss, C. & Eppenberger, H. Lack of actin III in fibrillar flight muscle of flightless Drosophila mutant raised. Nature 291, 506–508 (1981). https://doi.org/10.1038/291506a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/291506a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
