Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Characterisation of an adrenal zona glomerulosa-stimulating component of posterior pituitary extracts as α-MSH

Nature volume 284, pages 464–467 (1980)Cite this article

Abstract

The secretion of aldosterone from the zona glomerulosa of the mammalian adrenal cortex is stimulated by ACTH, potassium, angiotensin II and III, growth hormone, serotonin and E series prostaglandins1–7. Some experimental and clinical studies suggest that additional stimulants of the zona glomerulosa must exist, possibly including pituitary factors other than ACTH6,8–13. The possibility that posterior pituitary extracts may contain a zona glomerulosa stimulant was first suggested 20 years ago14,15, but has since received little attention. We describe here the purification from posterior pituitary extracts of activities that stimulate rat glomerulosa cells and whole tissue in vitro. One of the active compounds has been identified as α-MSH (melano-cyte stimulating hormone).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Haning, R., Tait, J. F. & Tait, S. A. S. Endocrinology 87, 1147–1167 (1970).

    Article  CAS  Google Scholar 

  2. Müller, J. Regulation of Aldosterone Biosynthesis (Springer, Berlin, 1971).

    Book  Google Scholar 

  3. Blair-West, J. R. et al. J. clin. Endocr. 32, 575–578 (1971).

    Article  CAS  Google Scholar 

  4. Vinson, G. P., Whitehouse, B. J., Goddard, C. & Sibley, C. P. J. Endocr. 81, 5P–24P (1979).

    CAS  PubMed  Google Scholar 

  5. Spät, A. & Jozan, S. J. Endocr. 65, 55–63 (1975).

    Article  Google Scholar 

  6. Palmore, W. P., Anderson, R. & Mulrow, P. J. Endocrinology 86, 728–734 (1970).

    Article  CAS  Google Scholar 

  7. Urquhart, J. in Handbook of Physiology Vol. 4, Sect. 7 (eds Greep, R. O. & Astwood, E. B.) 133–157 (American Physiological Society, Washington, 1974).

    Google Scholar 

  8. Ganong, W. F., Pemberton, P. L. & Van Brunt, E. E. Endocrinology 81, 1147–1150 (1967).

    Article  CAS  Google Scholar 

  9. Palmore, W. P. & Mulrow, P. J. Science 158, 1482–1484 (1967).

    Article  ADS  CAS  Google Scholar 

  10. Lee, T. C. Van der Wal, B. & de Wied, D. J. Endocr. 42, 265–275 (1968).

    Article  Google Scholar 

  11. Solyom, J., Ludwig, E. & Vajda, A. Acta physiol. acad. Sci. hung. 39, 343–349 (1971).

    CAS  PubMed  Google Scholar 

  12. Williams, G. H., Rose, L. I., Dluhy, R. G., Dingham, J. F. & Lawler, D. J. clin. Endocr. 32, 27–35 (1971).

    Article  CAS  Google Scholar 

  13. Palkovits, M., de Jong, W. & de Wied, D. Neuroendocrinology 14, 297–309 (1974).

    Article  CAS  Google Scholar 

  14. Giroud, C. J. P., Stachenko, J. & Piletta, P. in An International Symposium on Aldosterone (eds Müller, A. F. & O'Conner, C. M.) 56 (Churchill, London, 1958).

    Google Scholar 

  15. Venning, E. H., Lucis, O. J., Dyrenfurth, I. & Beck, J. C. in The Human Adrenal Cortex (eds Currie, A. R., Symington, T. & Grant, J. K.) 185–195 (Livingstone, Edinburgh, 1962).

    Google Scholar 

  16. Kaplan, N. O. & Lipman, F. J. biol. Chem. 174, 37–44 (1948).

    CAS  Google Scholar 

  17. Douglas, J., Aguilera, G., Kondo, T. & Catt, K. J. Endocrinology 102, 685–696 (1978).

    Article  CAS  Google Scholar 

  18. Richardson, M. C. & Schulster, D. J. Endocr. 55, 127–139 (1972).

    Article  CAS  Google Scholar 

  19. Silman, R. E. et al. J. Endocr. 81, 19–34 (1979).

    Article  CAS  Google Scholar 

  20. Vinson, G. P., Whitehouse, B. J., Goddard, C. & Sibley, C. P. J. Steroid Biochem. 11, 175–183 (1979).

    Article  CAS  Google Scholar 

  21. Whitehouse, B. J. & Vinson, G. P. J. Endocr. 77, 8P–9P (1978).

    CAS  PubMed  Google Scholar 

  22. Morris, H. R., Etienne, A. T., Dell, A. & Albuquerque, R. J. Neurochem. 34, 574–582 (1980).

    Article  CAS  Google Scholar 

  23. O'Hare, M. J. & Nice, E. C. J. Chromatogr. 171, 209–226 (1979).

    Article  CAS  Google Scholar 

  24. Morris, H. R. FEBS Lett. 22, 257–260 (1972).

    Article  CAS  Google Scholar 

  25. Stone, J. V., Mordue, W., Batley, K. E. & Morris, H. R. Nature 263, 207–211 (1976).

    Article  ADS  CAS  Google Scholar 

  26. Morris, H. R. & Dell, A. in Instrumentation in Amino Acid Sequence Analysis (ed. Perham, R. N.) (Academic, London, 1975).

    Google Scholar 

  27. Heilmann, J., Barrolier, J. & Watzke, E. Hoppe-Seyler's Z. physiol. Chem. 309, 219–220 (1957).

    Article  CAS  Google Scholar 

  28. Van der Wal, B. & de Wied, D. Acta endocr. 59, 186–192 (1968).

    Article  CAS  Google Scholar 

  29. Page, R. B., Boyd, J. E. & Mulrow, P. J. Endocr. Res. Commun. 1, 53–62 (1974).

    Article  CAS  Google Scholar 

  30. Glickman, J. A., Carson, G. D. & Challis, J. R. G. Endocrinology 104, 34–39 (1979).

    Article  CAS  Google Scholar 

  31. Llanos, A. J., Ramachandran, J., Creasy, R. K., Rudolph, A. M. & Serón-Ferré, M. Endocrinology 105, 613–617 (1979).

    Article  CAS  Google Scholar 

  32. Walsh, S. W., Norman, R. L. & Novy, M. J. Endocrinology 104, 1805–1813 (1979).

    Article  CAS  Google Scholar 

  33. Thody, A. J., Penny, R. J., Clark, D. & Taylor, C. J. Endocr. 67, 385–395 (1975).

    Article  CAS  Google Scholar 

  34. Duchen, L. W. J. Endocr. 25, 161–168 (1962).

    Article  CAS  Google Scholar 

  35. Howe, A. & Thody, A. J. J. Endocr. 46, 207–208 (1970).

    Article  Google Scholar 

  36. Kobayashi, Y. & Takena, M. Cell Tissue Res. 168, 153–159 (1976).

    Article  CAS  Google Scholar 

  37. Aguilera, G. & Katt, K. J. Endocrinology 104, 1046–1052 (1979).

    Article  CAS  Google Scholar 

  38. Birkhäuser, M., Gaillard, R., Riondel, A. M. & Zahnd, G. R. Acta endocr. 79, 16–24 (1975).

    Article  Google Scholar 

  39. Blair-West, J. R. et al. J. clin. Invest. 41, 1606–1627 (1962).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, St Bartholomew's Medical College, Charterhouse Square, London, EC1M 6BQ, UK

    Gavin P. Vinson

  2. Department of Physiology, Queen Elizabeth College, Campden Hill Road, London, W8 7AH, UK

     Barbara J. Whitehouse

  3. Department of Biochemistry, Imperial College, London, SW7 2AZ, UK

     Anne Dell,  Tony Etienne &  Howard R. Morris

Authors
  1. Gavin P. Vinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2.  Barbara J. Whitehouse
    View author publications

    You can also search for this author in PubMed Google Scholar

  3.  Anne Dell
    View author publications

    You can also search for this author in PubMed Google Scholar

  4.  Tony Etienne
    View author publications

    You can also search for this author in PubMed Google Scholar

  5.  Howard R. Morris
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vinson, G., Whitehouse,  ., Dell,  . et al. Characterisation of an adrenal zona glomerulosa-stimulating component of posterior pituitary extracts as α-MSH. Nature 284, 464–467 (1980). https://doi.org/10.1038/284464a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/284464a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing