Abstract
MULTIPLE forms of myosin are known to be present in vertebrate striated muscle. On the basis of the light-chain pattern and of other structural and enzymatic features, three distinct types of myosin have been identified in fast-skeletal, slow-skeletar and cardiac muscles of mammals and birds1–5. Although skeletal muscle fibre heterogeneity has been generally recognised in these comparative studies, it has always been tacitly assumed that cardiac muscle consists of a homogeneous cell population in terms of myosin. However, the heart comprises muscle cells which differ in structure and function, such as atrial cells, ventricular cells and the specialised cells of the conducting system. We report here immunohistochemical evidence for the existence of distinct myosins in these different muscle cell types in the chicken heart.
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SARTORE, S., PIEROBON-BORMIOLI, S. & SCHIAFFINO, S. Immunohistochemical evidence for myosin polymorphism in the chicken heart. Nature 274, 82–83 (1978). https://doi.org/10.1038/274082a0
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DOI: https://doi.org/10.1038/274082a0
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