Abstract
ANTISERUM can potentially interfere with effective immunity at three different parts of the immune response: afferent, central and efferent1–6. Coating or masking of antigenic sites on tumour cells with antiserum could render the cells non-immunogenic1,2—called afferent block—or protect them from attack by immune lymphocytes3,4—called efferent block. In central interference, the ability of the lymphocytes to become sensitised against tumour antigens is suppressed, or immune cells are made non-reactive by the humoral factors5,6. Most early studies in this area were performed with tumour allografts or used antisera with antigenic specificities which were not well characterised. Only a few studies have been performed with syngeneic tumours7,8. Because of the complexity of surface antigens expressed on tumour cells, the effects of the antisera on the tumour-associated transplantation antigen (TATA) was therefore difficult to assess.
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TING, CC., HERBERMAN, R. Specific afferent interference by antiserum of in vivo immunity. Nature 257, 801–802 (1975). https://doi.org/10.1038/257801a0
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DOI: https://doi.org/10.1038/257801a0
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