Abstract
IT has been shown that transferable drug resistance factors (R-factors) are composed of two basically independent entities1–5: (1) genetic determinants for drug resistance; (2) transfer factors, which are linked to the determinants to form complexes which are transferred from donor to recipient cells by conjugation. In the absence of a transfer factor, resistance determinants are transmitted only in a linear fashion. In the absence of resistance determinants, the transfer factors have no resistance to transfer.
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ANDERSON, E., PERRET, D. Mobilization of Transduced Tetracycline Resistance by the Δ Transfer Factor in Salmonella typhimurium and S. typhi. Nature 214, 810–811 (1967). https://doi.org/10.1038/214810b0
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DOI: https://doi.org/10.1038/214810b0
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