Abstract
VITAMIN A deficiency seems to cause negative nitrogen balance in young rats1. In a preliminary report, Abdulnabi and Bieri2 indicated that in vitamin A-deficient as compared to pair-fed normal rats, the tyrosine- and phenylalanine-levels in the testes are increased and the threonine concentration of the liver shows a decrease. These results were obtained with microbiological assays, since paper chromatography failed to reveal any significant differences. We have compared the free amino-acid composition in blood, liver and kidneys of vitamin A-deficient and pair-fed normal rats by paper chromatography. Our results confirm the earlier observations of Abdulnabi and Bieri2 and show significant increase in the phenylalanine- and tyrosine-levels, and a simultaneous significant decrease in the threonine values in all the three tissues of the deficient rats.
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MALATHI, P., SASTRY, P. & GANGULY, J. Amino-Acid Patterns in Vitamin A-deficient Rats. Nature 189, 660–661 (1961). https://doi.org/10.1038/189660a0
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DOI: https://doi.org/10.1038/189660a0
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