Abstract
THE rate of hæmolysis produced in vitro by the hæmolytic substance isolated from normal blood plasma1 has been found to be decreased on addition of antimalarial drugs in low concentration (1: 5,000 to 1: 40,000). Closely related inactive compounds did not affect the rate of hæmolysis. Quinine, 1: 10,000, for example, delayed the lysis time from one minute in the control to between 20 and 30 minutes, while a number of inactive quinoline, quinaldine and quinidine compounds failed to affect the rate of lysis.
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laser, H., and Friedmann, E., Nature, 156, 507 (1945).
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LASER, H. A Method of Testing the Antimalarial Properties of Compounds in vitro. Nature 157, 301 (1946). https://doi.org/10.1038/157301a0
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DOI: https://doi.org/10.1038/157301a0
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