Abstract
Guha and Ghosh1 found that rat liver incubated with mannose produced ascorbic acid, and followed it up by showing that parenteral administration of mannose also produced ascorbic acid in the rat tissue and notably in the liver. Euler et al.2 were unable to confirm the in vitro results, which was explained as due to the absence of molecular oxygen3 as Euler's experiment was made in an atmosphere of nitrogen. However, Hawthorne and Harrison4 and Klodt5 also could not confirm Guha's results in vitro or in vivo.
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References
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Arch. Exp. Path. Pharm., 189, 157 (1938).
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RUDRA, M. Role of Manganese in the Biological Synthesis of Ascorbic Acid. Nature 143, 811 (1939). https://doi.org/10.1038/143811a0
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DOI: https://doi.org/10.1038/143811a0
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