Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Paper
  • Published:

The cDNA cloning of the transcripts of human PEBP2αA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia

Oncogene volume 15, pages 367–371 (1997)Cite this article

Abstract

PEBP2/CBF is a heterodimeric transcription factor composed of α and β subunits. There are at least three closely related genes, PEBP2αA/Cbfa1, AML1/PEBP2αB/Cbfa2 and PEBP2αC/Cbfa3, encoding the α subunit and one β subunit encoding gene. Structural alterations of AML1 and the β subunit gene by chromosome translocations are frequently associated with several types of human leukemia. Structural changes of any of these gene products would have potential to affect the function of others. In this study, we isolated the human PEBP2αA cDNA by which we mapped the gene to 6p12.3-p21.1. Human chromosome 6p21 is the locus for cleidocranial dysplasia, an autosomal dominant bone disease. Recent gene disruption study revealed that PEBP2αA/Cbfa1 plays an essential role in osteogenesis (Komori et al., Cell, 1997, in press). Therefore, a close relationship between human PEBP2αA/CBFA1 and this bone disease is strongly implicated.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Author notes

  1. Ei-ichi Takahashi

    Present address: Otsuka GEN Research Institute, Otsuka Pharmaceutical Co. Ltd., 463-10 Kagasumo, Kawauchi, Tokushima, 771-01, Japan

Authors and Affiliations

  1. Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto, 606, Japan

    Yu-Wen Zhang & Yoshiaki Ito

  2. College of Medicine Chungbuk National University, Chungju, 360-763, Korea

    Suk-Chul Bae

  3. Division of Genetics, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263, Japan

    Ei-ichi Takahashi

Authors
  1. Yu-Wen Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suk-Chul Bae
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ei-ichi Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiaki Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhang, YW., Bae, SC., Takahashi, Ei. et al. The cDNA cloning of the transcripts of human PEBP2αA/CBFA1 mapped to 6p12.3-p21.1, the locus for cleidocranial dysplasia. Oncogene 15, 367–371 (1997). https://doi.org/10.1038/sj.onc.1201352

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1201352

Keywords

This article is cited by

Search

Advanced search

Quick links