Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

The first structure of a sea anemone potassium channel toxin reveals how a novel structural scaffold can be used to present key functional groups for channel blockade.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Miller, C. Science 252, 1092–1096 (1991).

    Article  CAS  Google Scholar 

  2. Catterall, W.A. Ann. Rev. Biochem. 64, 493–531 (1995).

    Article  CAS  Google Scholar 

  3. Harvey, A.L. Med. Res. Rev. 13, 81–104 (1993).

    Article  CAS  Google Scholar 

  4. Bontems, F., Gilquin, B., Roumestand, C., Menez, A. & Toma, F. Biochemistry 31, 7756–7764 (1992).

    Article  CAS  Google Scholar 

  5. Johnson, B.A. & Sugg, E. Biochemistry 31, 8151–8159 (1992).

    Article  CAS  Google Scholar 

  6. Johnson, B.A., Stevens, S.P. & Williamson, J.M. Biochemistry 33, 15061–15070 (1994).

    Article  CAS  Google Scholar 

  7. Fernández, I. et al. Biochemistry 33, 14256–14263 (1994).

    Article  Google Scholar 

  8. Aiyar, J. et al. Neuron 15, 1169–1181 (1995).

    Article  CAS  Google Scholar 

  9. Krezel, A.M., Kasibhatla, C., Hidalgo, P., MacKinnon, R. & Wagner, G. Protein Sci. 4, 1478–1489 (1995).

    Article  CAS  Google Scholar 

  10. Park, C-S. & Miller, C. Biochemistry 31, 7749–7755 (1992).

    Article  CAS  Google Scholar 

  11. Stampe, P., Kolmakova-Partensky, L. & Miller, C. Biochemistry 33, 443–450 (1994).

    Article  CAS  Google Scholar 

  12. Goldstein, S.A.N., Pheasant, D.J. & Miller, C. Neuron 12, 1377–1388 (1994).

    Article  CAS  Google Scholar 

  13. Stocker, M. & Miller, C. Proc. Natl. Acad. Sci. USA 91, 9509–9513 (1994).

    Article  CAS  Google Scholar 

  14. Hidalgo, P. & MacKinnon, R. Science 268, 307–310 (1995).

    Article  CAS  Google Scholar 

  15. Aneiros, A. et al. Biochim. Biophys. Acta 1157, 86–92 (1993).

    Article  CAS  Google Scholar 

  16. Castañeda, O. et al. Toxicon 33, 603–613 (1995).

    Article  Google Scholar 

  17. Pennington, M.W. et al. Intl. J. Pept. Prot. Res. 46, 354–358 (1995).

    Article  CAS  Google Scholar 

  18. Leonard, R.J., Garcia, M.L., Slaughter, R.S. & Reuben, J.P. Proc. Natl. Acad. Sci. USA 89, 10094–10098 (1992).

    Article  CAS  Google Scholar 

  19. Lin, C.S. et al. J. Exp. Med. 177, 637–645 (1993).

    Article  CAS  Google Scholar 

  20. Pohl, J. et al. Lett. Pept. Sci. 1, 291–297 (1995).

    Article  CAS  Google Scholar 

  21. Hyberts, S.G., Goldberg, M.S., Havel, T.F. & Wagner, G. Protein Sci. 1, 736–751 (1992).

    Article  CAS  Google Scholar 

  22. Seale, J.W., Srinivasan, R. & Rose, G.D. Protein Sci. 3, 1741–1745 (1994).

    Article  CAS  Google Scholar 

  23. Bernstein, F.C. et al. J. Mol. Biol. 112, 535–542 (1977).

    Article  CAS  Google Scholar 

  24. Holm, L. & Sander, C. J. Mol. Biol. 233, 123–138 (1993).

    Article  CAS  Google Scholar 

  25. Pennington, M.W. et al. Biochem. Biophys. Res. Commun. in the press (1996).

  26. Kim, J.I. et al. J. Biol. Chem. 269, 23876–23878 (1994).

    CAS  PubMed  Google Scholar 

  27. Pallaghy, P.K., Scanlon, M.J., Monks, S.A. & Norton, R.S. Biochemistry 34, 3782–3794 (1995).

    Article  CAS  Google Scholar 

  28. Monks, S.A., Pallaghy, P.K., Scanlon, M.J. & Norton, R.S. Structure 3, 791–803 (1995).

    Article  CAS  Google Scholar 

  29. Kraulis, P.J. Appl. Crystallogr. 24, 946–950 (1991).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tudor, J., Pallaghy, P., Pennington, M. et al. Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone. Nat Struct Mol Biol 3, 317–320 (1996). https://doi.org/10.1038/nsb0496-317

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0496-317

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing