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Loss of phasic dopamine: a new addiction marker?

Nature Neuroscience volume 17, pages 644–646 (2014)Cite this article

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A study finds that the loss of phasic dopamine signal in ventral, but not dorsal, striatum predicts escalation of cocaine self-administration. We discuss the study's implications for addiction theory and treatment.

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Figure 1: Comparison of in vivo observations of phasic dopamine changes by Willuhn et al.7 with the predictions of three prominent addiction theories for phasic dopamine neurotransmission during escalation of cocaine self-administration.

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Authors and Affiliations

  1. Department of Health and Human Services, Daniele Caprioli, Donna Calu and Yavin Shaham are in the Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, US National Institutes of Health, Baltimore, Maryland, USA.,

    Daniele Caprioli, Donna Calu & Yavin Shaham

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  1. Daniele Caprioli
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  2. Donna Calu
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  3. Yavin Shaham
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Correspondence to Yavin Shaham.

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Caprioli, D., Calu, D. & Shaham, Y. Loss of phasic dopamine: a new addiction marker?. Nat Neurosci 17, 644–646 (2014). https://doi.org/10.1038/nn.3699

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