Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses

Nature Immunology volume 4, pages 641–643 (2003)Cite this article

New insights into APOBEC editing functions suggest this family of enzymes might protect against invasive attack by foreign DNA.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Innate immunity mediated by APOBEC3G.

References

  1. Mangeat, B. et al. Nature advance online publication, 28 May 2003 (doi:10.1038/nature01709).

  2. Zhang, H. et al. Nature advance online publication, 28 May 2003 (doi:10.1038/nature01707).

  3. Harris, R.S. et al. Cell 113, 803–809 (2003); published online 28 May 2003. (doi:10.1016/S0092867403004329).

    Article  CAS  Google Scholar 

  4. Lecossier, D. et al. Science 300, 1112 (2003).

    Article  CAS  Google Scholar 

  5. Sheehy, A.M. et al. Nature 418, 646–650 (2002).

    Article  CAS  Google Scholar 

  6. Muramatsu, M. et al. Cell 102, 553–563 (2000).

    Article  CAS  Google Scholar 

  7. Revy, P. et al. Cell 102, 565–575 (2000).

    Article  CAS  Google Scholar 

  8. Neuberger, M.S. et al. Trends Biochem. Sci. advance online publication, 23 May 2003 (doi:2010.1016/S0968-0004(2003)00111-00117).

  9. Harris, R.S., Petersen-Mahrt, S.K. & Neuberger, M.S. Mol. Cell 10, 1247–1253 (2002).

    Article  CAS  Google Scholar 

  10. Jarmuz, A. et al. Genomics 79, 285–296 (2002).

    Article  CAS  Google Scholar 

  11. Blanc, V. & Davidson, N.O. J. Biol. Chem. 278, 1395–1398 (2003).

    Article  CAS  Google Scholar 

  12. Muramatsu, M. et al. J. Biol. Chem. 274, 18470–18476 (1999).

    Article  CAS  Google Scholar 

  13. Simon, J.H. et al. EMBO J. 17, 1259–1267 (1998).

    Article  CAS  Google Scholar 

  14. Vartanian, J.P. et al. J. Virol. 65, 1779–1788 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Li, Y. et al. J. Virol. 65, 3973–3985 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Fitzgibbon, J.E., Mazar, S. & Dubin, D.T. AIDS Res. Hum. Retroviruses 9, 833–838 (1993).

    Article  CAS  Google Scholar 

  17. Borman, A.M. et al. Virology 208, 601–609 (1995).

    Article  CAS  Google Scholar 

  18. Vartanian, J.P., Henry, M. & Wain-Hobson, S. J. Gen. Virol. 83, 801–805 (2002).

    Article  CAS  Google Scholar 

  19. Janini, M. et al. J. Virol. 75, 7973–7986 (2001).

    Article  CAS  Google Scholar 

  20. Gabuzda, D.H. et al. J. Virol. 66, 6489–6495 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. von Schwedler, U. et al. J. Virol. 67, 4945–4955 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Bransteitter, R. et al. Proc. Natl. Acad. Sci. USA 100, 4102–4107 (2003).

    Article  CAS  Google Scholar 

  23. Chaudhuri, J. et al. Nature 422, 726–730 (2003).

    Article  CAS  Google Scholar 

  24. Petersen-Mahrt, S.K. & Neuberger, M.S. J. Biol. Chem. 278, 19583–19586 (2003).

    Article  CAS  Google Scholar 

  25. Dickerson, S.K. et al. J. Exp. Med. 197, 1291–1296 (2003).

    Article  CAS  Google Scholar 

  26. Lindahl, T. & Wood, R.D. Science 286, 1897–1905 (1999).

    Article  CAS  Google Scholar 

  27. Simon, J.H. & Malim, M.H. J. Virol. 70, 5297–5305 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Klarmann, G.J. et al. J. Biol. Chem. 278, 7902–7909 (2003).

    Article  CAS  Google Scholar 

  29. Gunther, S. et al. Virology 235, 104–108 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    Reuben S Harris & Michael S Neuberger

  2. Department of Infectious Diseases, Guy's, King's and St. Thomas' School of Medicine, King's College London, London, SE1 9RT, UK

    Ann M Sheehy, Heather M Craig & Michael H Malim

Authors
  1. Reuben S Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ann M Sheehy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Heather M Craig
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael H Malim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Michael S Neuberger
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Reuben S Harris or Michael S Neuberger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harris, R., Sheehy, A., Craig, H. et al. DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. Nat Immunol 4, 641–643 (2003). https://doi.org/10.1038/ni0703-641

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0703-641

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing