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The relationship between chromosome structure and function at a human telomeric region

Nature Genetics volume 15, pages 252–257 (1997)Cite this article

Abstract

We have sequenced a contiguous 284, 495-bp segment of DNA extending from the terminal (TTAGGG)n repeats of the short arm of chromosome 16, providing a full description of the transition from telomeric through subtelomeric DNA to sequences that are unique to the chromosome. To complement and extend analysis of the primary sequence, we have characterized mRNA transcripts, patterns of DNA methylation and DNase I sensitivity. Together with previous data these studies describe in detail the structural and functional organization of a human telomeric region.

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Author information

Authors and Affiliations

  1. The MRC Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK

    Jonathan Flint, Helen Raynham, Kevin Clark & Douglas R. Higgs

  2. The Sanger Centre, HinxtonHall, Cambridge, CB10 1RQ, UK

    Karen Thomas, Gos Micklem & Andrew Andrew

  3. Life Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA

    Norman A. Doggett

Authors
  1. Jonathan Flint
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  2. Karen Thomas
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  4. Helen Raynham
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  8. Douglas R. Higgs
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Correspondence to Douglas R. Higgs.

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Flint, J., Thomas, K., Micklem, G. et al. The relationship between chromosome structure and function at a human telomeric region. Nat Genet 15, 252–257 (1997). https://doi.org/10.1038/ng0397-252

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