Molecular Therapy
Volume 20, Issue 7, July 2012, Pages 1298-1304
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Review
In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?

https://doi.org/10.1038/mt.2012.79Get rights and content
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The promise of cancer gene therapeutics is hampered by difficulties in the in vivo delivery to the targeted tumor cells, and systemic delivery remains to be the biggest challenge to be overcome. Here, we concentrate on systemic in vivo gene delivery for cancer therapy using nonviral vectors. In this review, we summarize the existing delivery barriers together with the requirements and strategies to overcome these problems. We will also introduce the current progress in the design of nonviral vectors, and briefly discuss their safety issues.

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published online 24 April 2012