ArticleSuppression of islet homeostasis protein thwarts diabetes mellitus progression
Under an Elsevier user license
open archive
Cited by (0)
Supplementary Information accompanies the paper on the Laboratory Investigation website
Islet homeostasis protein (IHoP) co-localizes within pancreatic a-cells and is over-expressed in the islets of post-onset non-obese diabetic (NOD) mice and Type-1 diabetic patients. Suppression of IHoP during pre-diabetes altered the immune response producing normoglycemia in NOD mice for 35 weeks. IHoP levels increase in diabetic serum, indicating possible application as a biomarker.
Supplementary information The online version of this article (doi:10.1038/labinvest.2017.15) contains supplementary material, which is available to authorized users.
© 2017 United States & Canadian Academy of Pathology.