Research ArticlePathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane
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Keywords
animal model
B cells
diffuse alveolar hemorrhage
pristane
systemic lupus erythematosus
Cited by (0)
A single intraperitoneal injection of pristane induces alveolar hemorrhage in C57BL/6 mice within two weeks. The effect is independent of MyD88, TLR7, FcγR, TCR, and Fas; however, absence of B-cells reduces the prevalence. This model can be useful for determining the pathogenesis of this life-threatening complication and for testing new therapies.
© 2011 United States & Canadian Academy of Pathology.