Abstract
New antibiotic polyketides, named aurafuron A (1) and B (2) were isolated from culture extracts of myxobacteria of the species Stigmatella aurantiaca and Archangium gephyra, strain Ar 10844. By multi-step chromatography 1 and 2 were separated from a variety of other non-related co-metabolites, and their structures elucidated by spectroscopic methods as new 5-alkenyl-3 3(2H)-furanones. Aurafurons inhibited the growth of some filamentous fungi and additionally, aurafuron B was weakly active against few Gram-positive bacteria. Both compounds also showed cytotoxic activity against the mouse fibroblast cell line L929.
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Article No. 102 on antibiotics from gliding bacteria. Article No. 101: Wenzel SC, Kunze B, Höfle G, Silakowski B, Scharfe M, Blöcker H, Müller R. ChemBioChem 6: 375-385 (2005)
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Kunze, B., Reichenbach, H., Müller, R. et al. Aurafuron A and B, New Bioactive Polyketides from Stigmatella aurantiaca and Archangium gephyra (Myxobacteria). J Antibiot 58, 244–251 (2005). https://doi.org/10.1038/ja.2005.28
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DOI: https://doi.org/10.1038/ja.2005.28
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