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Transplant Toxicities

The impact of center accreditation on hematopoietic cell transplantation (HCT)

Bone Marrow Transplantation volume 50, pages 87–94 (2015)Cite this article

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Abstract

There are two voluntary center-accrediting organizations in the USA, the Foundation for the Accreditation of Cellular Therapy (FACT) and core Clinical Trial Network (CTN) certification, that are thought to improve and ensure hematopoietic cell transplantation (HCT) center quality care and certify clinical excellence. We sought to observe whether there are differences in outcomes between HLA-matched and -mismatched HCT by CTN and FACT status. Using the 2008–2010 Center for International Blood & Marrow Transplant Research data we created three center categories: non-FACT centers (24 centers), FACT-only certified centers (106 centers) and FACT and core clinical trial network (FACT/CTN) certified centers (32 centers). We identified patient characteristics within these centers and the relationship between FACT certification and survival. Our cohort consisted of 12 993 transplants conducted in 162 centers. After adjusting for patient and center characteristics we found that FACT/CTN centers had consistently superior results relative to non-FACT and FACT-only centers (P<0.05) especially for more complex HCT. However, non-FACT centers were comparable to FACT-only centers for matched related and unrelated patients. Although FACT status is an important standard of quality control that begins to define improved OS, our results indicate that FACT status alone is not an indicator for superior outcomes.

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Authors and Affiliations

  1. School of Medicine, University of Minnesota, Minneapolis, MN, USA

    S Marmor

  2. Division of Health Policy & Management, School of Public Health, University of Minnesota, Minneapolis, MN, USA

    J W Begun, J Abraham & B A Virnig

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  1. S Marmor
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  2. J W Begun
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Correspondence to S Marmor.

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Marmor, S., Begun, J., Abraham, J. et al. The impact of center accreditation on hematopoietic cell transplantation (HCT). Bone Marrow Transplant 50, 87–94 (2015). https://doi.org/10.1038/bmt.2014.219

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