Three recent X-ray structures of the anti-apoptotic protein survivin reveal two different dimeric interfaces. More experiments are needed to determine the biologically relevant dimer interface and to probe survivin function on the basis of its structure.
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Acknowledgements
The author thanks J. Noel for communicating unpublished data, J. Noel and O. Dideberg for the atomic coordinates of human survivin and S. Muchmore for help with the preparation of Fig. 3.
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Shi, Y. Survivin structure: crystal unclear. Nat Struct Mol Biol 7, 620–623 (2000). https://doi.org/10.1038/77904
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DOI: https://doi.org/10.1038/77904
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