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One motif — many different reactions

Nature Structural Biology volume 7, pages 182–184 (2000)Cite this article

The structure of the trifunctional clavaminic acid synthase exhibits an emerging structural motif found among nonheme iron oxygen activating enzymes that provides the metal active site the flexibility to catalyze a remarkable range of reactions.

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Figure 1: Active site structures of representative nonheme iron enzymes with a 2-His-1-carboxylate facial triad and the reactions they catalyze.
Figure 2: Structures of the active sites of three nonheme iron enzymes.

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  1. Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, 207 Pleasant St. SE, Minneapolis, 55455, Minnesota, USA

    Lawrence Que Jr

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  1. Lawrence Que Jr
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Que, L. One motif — many different reactions. Nat Struct Mol Biol 7, 182–184 (2000). https://doi.org/10.1038/73270

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