Acetaldehyde, a reactive metabolite of ethanol, can damage DNA unless properly processed. A biochemical pathway involved in Fanconi anaemia seems to be essential for protection against such damage. See Article p.53
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Joenje, H. Alcohol, DNA and disease. Nature 475, 45–46 (2011). https://doi.org/10.1038/475045a
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DOI: https://doi.org/10.1038/475045a