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The B-cell antigen receptor of the five immunoglobulin classes

Nature volume 352, pages 777–781 (1991)Cite this article

Abstract

Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the α and β associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, α common a chain associ-ates with all five immunoglobulin classes. We pro-pose that B-cell antigen receptors consist of a common α/β heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated α chain and in their dependence on α/β for surface transport.

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References

  1. Sell, S. & Gell, P. G. H. J. exp. Med. 122, 423–439 (1965).

    Article  CAS  Google Scholar 

  2. Sidman, C. L. & Unanue, E. R. Nature 257, 149–151 (1975).

    Article  ADS  CAS  Google Scholar 

  3. Vitetta, E., Pure, E. R., Isakson, P., Buck, L. & Uhr, J. Immun. Rev. 52, 211–231 (1980).

    Article  CAS  Google Scholar 

  4. Lanzavecchia, A. Nature 314, 537–539 (1985).

    Article  ADS  CAS  Google Scholar 

  5. Koch, N. & Haustein, D. Molec. Immun. 20, 33–37 (1983).

    Article  CAS  Google Scholar 

  6. Haustein, D. & Von der Ahe, D. Eur. J. Immun. 16, 113–115 (1986).

    Article  CAS  Google Scholar 

  7. Hombach, J., Leclercq, L., Radbruch, A., Rajewsky, K. & Reth, M. G. EMBO J. 7, 3451–3456 (1988).

    Article  CAS  Google Scholar 

  8. Hombach, J., Lottspeich, F. & Reth, M. Eur. J. Immun. 20, 2795–2799 (1990).

    Article  CAS  Google Scholar 

  9. Campbell, K. S. & Cambier, J. C. EMBO J. 9, 441–448 (1990).

    Article  CAS  Google Scholar 

  10. Chen, J., Stall, A. M., Herzenberg, L. A. & Herzenberg, L. A. EMBO J. 9, 2117–2124 (1990).

    Article  CAS  Google Scholar 

  11. Parkhouse, R. M. E. Immunology 69, 298–302 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Matsuo, T., Kimoto, M. & Sakaguchi, N. J. Immun. 146, 1584–1590 (1991).

    CAS  PubMed  Google Scholar 

  13. Sakaguchi, N., Kashiwamura, S., Kimoto, M., Thalmann, P. & Melchers, F. EMBO J. 7, 3457–3464 (1988).

    Article  CAS  Google Scholar 

  14. Hermanson, G. G., Eisenberg, D., Kincade, P. W. & Wall, R. Proc. natn. Acad. Sci. U.S.A. 85, 6890–6894 (1988).

    Article  ADS  CAS  Google Scholar 

  15. Hombach, J., Tsubata, T., Leclercq, L., Stappert, H. & Reth, M. Nature 343, 760–762 (1990).

    Article  ADS  CAS  Google Scholar 

  16. Sitia, R., Neuberger, M. S. & Milstein, C. EMBO J. 6, 3969–3977 (1987).

    Article  CAS  Google Scholar 

  17. Hombach, J., Sablitzky, F., Rajewsky, K. & Reth, M. J. exp. Med. 167, 652–657 (1988).

    Article  CAS  Google Scholar 

  18. Williams, G. T., Venkitaraman, A. R., Gilmore, D. J. & Neuberger, M. S. J. exp. Med. 171, 947–952 (1990).

    Article  CAS  Google Scholar 

  19. Gold, M. R., Matsuuchi, L., Kelly, R. B. & DeFranco, A. L. Proc. natn. Acad. Sci. U.S.A. 88, 3436–3440 (1991).

    Article  ADS  CAS  Google Scholar 

  20. Scott, D. W., Layton, J. E. & Nossal, G. J. V. J. exp. Med. 146, 1473–1483 (1977).

    Article  CAS  Google Scholar 

  21. Vitetta, E. S., Cambier, J. C., Ligler, F. S., Kettman, J. R. & Uhr, J. W. J. exp. Med. 146, 1804–1808 (1977).

    Article  CAS  Google Scholar 

  22. Tisch, R., Roifman, C. M. & Hozumi, N. Proc. natn. Acad. Sci. U.S.A. 85, 6914–6918 (1988).

    Article  ADS  CAS  Google Scholar 

  23. Alés-Martinez, J. E., Warner, G. L. & Scott, D. W. Proc. natn. Acad. Sci. U.S.A. 85, 6919–6923 (1988).

    Article  ADS  Google Scholar 

  24. Wienands, J., Hombach, J., Radbruch, A., Riesterer, C. & Reth, M. EMBO J. 9, 449–455 (1990).

    Article  CAS  Google Scholar 

  25. Evan, G. I., Lewis, G. K., Ramsay, G. & Bishop, J. M. Molec. cell. Biol. 5, 3610–3616 (1985).

    Article  CAS  Google Scholar 

  26. Sitia, R. et al. Cell 60, 781–790 (1990).

    Article  CAS  Google Scholar 

  27. Neuberger, M. S. & Rajewsky, K. Proc. natn. Acad. Sci. U.S.A. 78, 1138–1142 (1981).

    Article  ADS  CAS  Google Scholar 

  28. Liesegang, B., Radbruch, A. & Rajewsky, K. Proc. natn. Acad. Sci. U.S.A. 75, 3901–3905 (1978).

    Article  ADS  CAS  Google Scholar 

  29. Kishi, H. et al. EMBO J. 10, 93–100 (1991).

    Article  CAS  Google Scholar 

  30. Thompson, J. A., Lau, A. L. & Cunningham, D. D. Biochemistry 26, 743–750 (1987).

    Article  CAS  Google Scholar 

  31. Brüggemann, M., Winter, G. P., Waldmann, H. & Neuberger, M. S. J. exp. Med. 170, 2153–2157 (1989).

    Article  Google Scholar 

  32. Reth, M., Imanishi-Kari, T. & Rajewsky, K. Eur. J. Immun. 9, 1004–1013 (1979).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    Ashok R. Venkitaraman, Gareth T. Williams, Piona Dariavach & Michael S. Neuberger

  2. Laboratoire d'lmmunogénétique Moléculaire, Université de Montpellier II, France

    Piona Dariavach

Authors
  1. Ashok R. Venkitaraman
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  2. Gareth T. Williams
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  3. Piona Dariavach
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  4. Michael S. Neuberger
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Venkitaraman, A., Williams, G., Dariavach, P. et al. The B-cell antigen receptor of the five immunoglobulin classes. Nature 352, 777–781 (1991). https://doi.org/10.1038/352777a0

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