Abstract
Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the α and β associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, α common a chain associ-ates with all five immunoglobulin classes. We pro-pose that B-cell antigen receptors consist of a common α/β heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated α chain and in their dependence on α/β for surface transport.
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Venkitaraman, A., Williams, G., Dariavach, P. et al. The B-cell antigen receptor of the five immunoglobulin classes. Nature 352, 777–781 (1991). https://doi.org/10.1038/352777a0
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DOI: https://doi.org/10.1038/352777a0
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