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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

Abstract

A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF.

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References

  1. Goodfellow, P. N. & Darling, S. M. Development 102, 251–258 (1988).

    CAS  PubMed  Google Scholar 

  2. Jost, A., Vigier, B., Prepin, J. & Perchellet, J. P. Recent Prog. Horm. Res. 29, 1–41 (1973).

    CAS  PubMed  Google Scholar 

  3. Vergnaud, G. et al. Am. J. hum. Genet. 38, 109–124 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Guellaen, G. et al. Nature 307, 172–173 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Goodfellow, P. J., Darling, S. M., Thomas, N. S. & Goodfellow, P. N. Science 234, 740–743 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Weissenbach, J., Levilliers, J., Petit, C., Rouyer, F. & Simmler, M.-C. Development 101S, 67–74 (1987).

    Google Scholar 

  7. Pritchard, C. A., Goodfellow, P. J. & Goodfellow, P. N. Nature 328, 273–275 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Ferguson-Smith, M. A. Lancet ii, 475–476 (1966).

    Article  Google Scholar 

  9. Petit, C. et al. Cell 49, 595–602 (1987).

    Article  CAS  PubMed  Google Scholar 

  10. Page, D. C. et al. Cell 51, 1091–1104 (1987).

    Article  CAS  PubMed  Google Scholar 

  11. Palmer, M. S., Berta, P., Sinclair, A. H., Pym, B. & Goodfellow, P. N. Proc. natn. Acad Sci. U.S.A. 87, 1681–1685 (1990).

    Article  ADS  CAS  Google Scholar 

  12. Schneider-Gädicke, A., Beer-Romero, P., Brown, L. G., Nussbaum, R. & Page, D. C. Cell 57, 1247–1258 (1989).

    Article  PubMed  Google Scholar 

  13. Sinclair, A. H. et al. Nature 336, 780–782 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Koopman, P., Gubbay, J., Collignon, J. & Lovell-Badge, R. Nature 342, 940–942 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Palmer, M. S. et al. Nature 342, 937–939 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Ellis, N. A. et al. Nature 337, 81–84 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Sealey, P. G., Whittaker, P. A. & Southern, E. M. Nucleic Acids Res. 13, 1905–1922 (1985).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Smith, T. F. & Waterman, M. S. J. molec. Biol. 147, 195–197 (1981).

    Article  CAS  PubMed  Google Scholar 

  19. Collins, J. F., Coulson, A. F. W. & Lyall, A. CABIOS 4, 67–71 (1988).

    CAS  PubMed  Google Scholar 

  20. Kelly, M., Burke, J., Smith, M., Klar, A. & Beach, D. EMBO J. 7, 1537–1547 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Jantzen, H.-M., Adman, A., Bell, S. P. & Tjian, R. Nature 344, 830–836 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Kolodrubetz, D. & Burgum, A. J. biol. Chem. 265, 3234–3239 (1990).

    CAS  PubMed  Google Scholar 

  23. Frohman, M. A., Dush, M. K. & Martin, G. R. Proc. natn. Acad. Sci. U.S.A. 85, 8998–9002 (1988).

    Article  ADS  CAS  Google Scholar 

  24. Gubbay, J. et al. Nature 346, 245–250 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. McLaren, A., Simpson, E., Tomonari, K., Chandler, P. & Hogg, H. Nature 312, 552–555 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Lovell-Badge, R. & Robertson, E. Development 109, 635–646 (1990).

    CAS  PubMed  Google Scholar 

  27. Wright, J. M. & Dixon, G. H. Biochemistry 27, 576–581 (1988).

    Article  CAS  PubMed  Google Scholar 

  28. Goodfellow, P. J. et al. Ann. hum. Genet 53, 15–22 (1989).

    Article  CAS  PubMed  Google Scholar 

  29. DeKretser, T. A., Crumpton, M. J., Bodmer, J. G. & Bodmer, W. F. Eur. J. Immun. 12, 600–606 (1982).

    Article  CAS  Google Scholar 

  30. Bishop, C. E. et al. Nature 303, 831–832 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Westerveld, A., Visser, R. P. L. S., Meera Khan, P. & Bootsma, D. Nature new Biol. 234, 20–24 (1971).

    Article  CAS  PubMed  Google Scholar 

  32. Goss, S. J. & Harris, H. Nature 255, 680–683 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  33. Burk, R. D., Ma, P. & Smith, K. D. Molec. cell. Biol. 5, 576–581 (1985).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  ADS  CAS  Google Scholar 

  35. Chomczynski, P. & Sacchi, N. Analyt. Biochem. 162, 156–159 (1987).

    Article  CAS  PubMed  Google Scholar 

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Sinclair, A., Berta, P., Palmer, M. et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 346, 240–244 (1990). https://doi.org/10.1038/346240a0

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