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A crucial epileptogenic site in the deep prepiriform cortex

Nature volume 317, pages 623–625 (1985)Cite this article

A Corrigendum to this article was published on 01 December 1985

Abstract

Antagonists of γ-aminobutyric acid (GABA)- or glycine-mediated neurotransmission, muscarinic cholinergic agonists, and excitatory amino acids and their analogues are all considered to be potent chemoconvulsant agents. However, although systemic injections of these agents have been used to create experimental models of generalized epilepsy, there has been no identification of a specific locus at which any of these drugs act to initiate generalized seizures. We recently located a forebrain region from which seizures can be elicited by the GABA antagonist bicuculline1, and now report that manipulations of excitatory amino acid transmission and cholinergic transmission can also elicit seizures from this site. Bilateral clonic seizures can be elicited after unilateral application of picomole amounts of bicuculline, kainic acid or carbachol and micromole amounts of glutamate. Local application of the GABA agonist muscimol prevents the appearance of seizures on subsequent microinjection of all convulsant agents examined, whereas local application of the muscarinic antagonist, atropine, only prevents seizures induced by carbachol. This region is therefore a site of action for the epileptogenic effects of neuroactive agents with diverse mechanisms of action; it may also represent a site at which GABA agonists could function therapeutically to control epileptogenesis.

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Authors and Affiliations

  1. Department of Pharmacology, Schools of Medicine and Dentistry, Washington, DC, 20007, USA

    Salvatore Piredda & Karen Gale

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  1. Salvatore Piredda
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  2. Karen Gale
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Piredda, S., Gale, K. A crucial epileptogenic site in the deep prepiriform cortex. Nature 317, 623–625 (1985). https://doi.org/10.1038/317623a0

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