Abstract
IN support of investigations on the ætiological role of chronic excess salt ingestion in human hypertension1 we have repeatedly induced experimental hypertension in rats by chronically feeding a diet high in sodium (chloride), similar to that described by Meneely et al.2. We have observed that, if high salt intakes are initiated at the time of weaning (3 weeks of age), such rats are much more prone to develop hypertension than are older animals. Meneely and Ball3 observed that 2-year-old rats developed significantly less hypertension than did younger rats on the same high sodium regimen. Investigations at present in progress here to quantify the physiological consequences of salt administration to youthful animals clearly confirm these previous experiences.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
a, Dahl, L. K., Nature, 181, 989 (1958). b, Dahl, L. K., in Essential Hypertension, An International Symposium, edit. by Cottier, P., and Bock, K. D., Berne, 53 (Springer-Verlag, Heidelberg, 1960). c, Dahl, L. K., Smilay, M. G., Silver, L., and Spraragen, S. C., Nature, 192, 267 (1961).
Meneely, G. R., Tucker, R. G., Darby, W. J., and Auerbach, S. D., J. Exp. Med., 98, 71 (1953).
Meneely, G. R., and Ball, C. O. T., Amer. J. Med., 25, 713 (1958).
Dahl, L. K., Tassinari, L. M., and Gillespie, N., J. Amer. Diet. Assoc., 34, 717 (1958).
a, Dahl, L. K., Heine, M., and Tassinari, L., J. Exp. Med., 115, 1173 (1962). b, Dahl, L. K., Heine, M., and Tassinari, L., Nature, 194, 480 (1962).
Blood and other Body Fluids, edit. by Dittmer, D. S., under the auspices of Committee on Biological Handbooks, Fed. Amer. Soc. Exp. Biol., Washington, D.C., 459 (1961).
Dahl, L. K., J. Exp. Med., 114, 231 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DAHL, L., HEINE, M. & TASSINARI, L. High Salt Content of Western Infant's Diet : Possible Relationship to Hypertension in the Adult. Nature 198, 1204–1205 (1963). https://doi.org/10.1038/1981204a0
Issue Date:
DOI: https://doi.org/10.1038/1981204a0
This article is cited by
-
Impact of nutrition since early life on cardiovascular prevention
Italian Journal of Pediatrics (2012)
-
Die Natriumaufnahme bei verschiedener Ern�hrung und ihre Beziehung zum Salzfieber bei kleinen S�uglingen
Zeitschrift f�r Kinderheilkunde (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.