Abstract
The pharmacokinetics of amikacin (AMK) were investigated after intravenous (i.v.) and intramuscular (i.m.) administration of 7.5 mg/kg bw in 6 healthy lactating sheep. After i.v. AMK injection (as a bolus), the elimination half-life (t 1/2), the volume of distribution (V d,area), the total body clearance (ClB) and the area under the concentration–time curve (AUC) were 1.64±0.06 h, 0.19±0.02 L/kg, 1.36±0.1 ml/min per kg and 94.09±6.95 (μg.h)/ml, respectively. The maximum milk concentration of AMK (C max), the area under the milk concentration–time curve (AUCmilk) and the ratio AUCmilk/AUCserum were 1.18±0.22 μg/ml, 22.45±3.21 (μg.h)/ml and 0.24±0.02, respectively. After i.m. administration of AMK the t 1/2β, C max, time of C max (t max) and absolute bioavailability (F abs) were 1.29±0.1 h, 16.97±1.54 μg/ml, 1.0±0 h and 64.88%±6.16%, respectively. The C max, AUCmilk and the ratio AUCmilk/AUCserum were 0.33 μg/ml, 1.67 (μg.h)/ml and 0.036, respectively.
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Haritova, A., Lashev, L. Pharmacokinetics of Amikacin in Lactating Sheep. Vet Res Commun 28, 429–435 (2004). https://doi.org/10.1023/B:VERC.0000035023.05511.11
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DOI: https://doi.org/10.1023/B:VERC.0000035023.05511.11