Abstract
Light and electron microscopy and morphometry were used to study the characteristics of the cytoarchitectonics of the sensorimotor cortex and the structures of neurons and their dendrites in 21- and 30-day-old baby rats born to chronically alcoholized females and males. Three categories of morphological changes were identified: signs of delayed maturation of neurons and dendrites, destructive changes to these structures, and signs of repair processes, with dynamics occurring during postnatal ontogenesis. At age three weeks, apart from delayed maturation of neurons and underdevelopment of the dendritic system, there were also spreading destructive changes. Increasing age was associated with increases in repair processes, though destructive changes to neurons persisted, which is evidence for the delayed action of alcohol intoxication of animals on the structural development of the brain in their offspring.
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REFERENCES
N. I. Artyukhina, “Effects of alcohol consumption by male and female rats on brain structure in offspring,” in: Alcoholism and Heredity [in Russian], Moscow (1987), pp. 30–33.
N. N. Bogolepov, N. I. Pavlovskaya, and N. I. Yakovleva, “Ultrastructure of contacts between paired neurons in the post-hypoxic period,” Arkh. Anat., 79, No. 9, 15–23 (1980).
N. A. Druzhinina, A. G. Mutalov, I. G. Shakhmuratova, and Yu. A. Druzhinin, “The state of health and the physical and neuropsychiatric development of offspring of parents with alcoholism,” Med. Pomoshch', No. 2, 9–11 (2001).
T. A. Emel'yanova, “The role of families with alcohol problems in forming deviant behavior in offspring,” in: Studies by Young Scientists: A Collection [in Russian], Minsk (2000), pp. 142–144.
V. N. Kleshchinov, V. I. Koidan, and N. S. Kolomeets, “Characteristics of hyperchromic neurons from a focus of local destruction,” Byull. Éksperim. Biol., 96, No. 8, 104–106 (1983).
D. D. Orlovskaya and V. N. Kleshchinov, “The neuron and its hyperchromic state,” Zh. Nevropatol. Psikhiatr., 86, No. 7, 981–988 (1986).
É. N. Popova, “Dystrophic and repair changes in cortical neurons in the offspring of rats with moderate prenatal alcoholization,” Morfologiya, 109, No. 2, 23–27 (1996).
É. N. Popova, V. B. Polyanskii, K. A. Nikol'skaya, et al., The Brain and Alcohol [in Russian], Nauka, Moscow (1984).
A. S. Stupina, T. Yu. Kvitnitskaya-Ryzhova, and N. A. Mezhiborskaya, “Structural changes in the brain,” in: Aging of the Brain [in Russian], Nauka, Leningrad (1991), pp. 7–42.
L. E. Frumkina, Postnatal Ontogenesis of Neurons and Interneuronal Connections of the Caudate Nucleus in Normal Conditions and in Alcohol Intoxication [in Russian], Author's abstract of thesis for doctorate in biological sciences, Moscow (1983).
E. N. Popova, “Maternal alcohol consumption before pregnancy and ultrastructure of neurons and interneuronal connections in rat offspring,” Int. J. Neurosci., 73, 37–45 (1993).
T. Tombol, “Morphological alteration of neurons of kittens prenatally exposed to ethanol.” Acta Morphol. Hung., 38, No. 3, 169–178 (1990).
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Popova, É.N. Structure of the Sensorimotor Area of the Cerebral Cortex in the Offspring of Alcoholized Rats. Neurosci Behav Physiol 34, 663–669 (2004). https://doi.org/10.1023/B:NEAB.0000036004.15139.36
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DOI: https://doi.org/10.1023/B:NEAB.0000036004.15139.36