Abstract
Of the eight different isolates of SEN virus (SENV), SENV-D and SENV-H have been suggested associated with transfusion-associated hepatitis. The prevalence and clinical significance of these two SENV strains among blood donors in southern Taiwan were investigated in this study. Sera of 223 blood donors who were negative for serum hepatitis B surface antigen (HBsAg) and third-generation HCV antibody (anti-HCV) from a blood center of southern Taiwan were tested for alanine aminotransferase (ALT), GB virus C/hepatitis G virus (GBV-C/HGV) anti-envelope protein 2 (anti-E2) antibody and RNA, and SENV-D and -H DNA. Of the 223 donors, the prevalence of SENV-D and/or -H (SENV-D/H), SENV-D, SENV-H DNA, GBV-C/HGV RNA, and anti-E2 were 24.2, 19.7, 5.8, 2.2, and 8.5%. The donors with SENV-D DNA had a significantly higher mean age than those without (31.2 ± 10.9 vs. 27.5 ± 8.3 years; P=0.014). No association between positive SENV DNA and gender, GBV-C/HGV exposure, mean ALT level, or abnormal ALT was found. Based on multiple logistic regression analysis, the increased age was the only independent factor associated with positive SENV-D DNA (odds ratio, 1.042; 95% confidence interval, 1.01–1.08). Nearly a fourth of blood donors in southern Taiwan were infected by SENV-D/H, with SENV-D more prevalent than SENV-H. Patients with higher ages have a higher prevalence of SENV-D. SENV-D or SENV-H infection was not associated with ALT levels.
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REFERENCES
Chuang WL, Chang WY, Lu SN, et al: The role of hepatitis C virus in chronic hepatitis B virus infection. Gastroenterol Jpn 28 (suppl 5):23–27, 1993
Chen DS, Wang JT, Chen PJ, Wan TH, Sung JL. Hepatitis C virus infection in Taiwan. Gastroenterol Jpn 26 (Suppl 3):164–166, 1991
Wang JH, Lu SN, Wu JC, et al: A hyperendemic community of hepatitis B virus and hepatitis C virus infection in Taiwan. Trans R Soc Trop Med Hyg 93:1–2, 1999
Simons JN, Leary TP, Dawson GL, et al: Isolation of novel viruslike sequences associated with human hepatitis. NatMed1:564–569, 1995
Linnen J, Wages J Jr, Zhang-Keck ZY, et al: Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.Science 271:505–508, 1996
Yoshiba M, Okamoto H, Mishiro S: Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown etiology. Lancet 346:1131–1132, 1995
Alter MJ, Gallagher M, Morris TT, et al: Acute non-A-E hepatitis in the United States and the role of hepatitis G virus infection. N Engl J Med 336:741–746, 1997
Alter HJ, Nakatsuji Y, Melpolder J, et al: The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. N Engl J Med 336:747–754, 1997
Yu ML, Chuang WL, Dai CY, et al: The serological and molecular epidemiology of GB virus C/hepatitisG virus infection in a hepatitis C and B endemic area. J Infect 42:61–66, 2001
Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M: A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology.Biochem Biophys Res Commun 241:92–97, 1997
Okamoto H, Nishizawa T, Kato N, Ukita M, Ikeda H, Iizuka H: Molecular cloning and characterization of a novel virus (TTV) associated with posttransfusion hepatitis of unknownetiology. Hepatol Res 10:1–16, 1998
Mushahwar IK, Erker JC, Muerhoff AS, et al: Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans. Proc Natl Acad Sci USA 96:3177–3182, 1999
Itoh K, Hirakawa K, Okamoto H, et al: Infection by an unenveloped DNA virus associated with non-A to-G hepatitis in Japanese blood donors with or without elevated ALT levels. Transfusion 39:522–526, 1999
Okamoto H, Nishizawa T, Ukita M:Anovel unenvelopedDNAvirus (TT virus) associated with acute and chronic non-A to G hepatitis.Intervirology 42:196–204, 1999
Hohne M, Berg T, Muller AR, Schreier E: Detection of sequences of TT virus, a novel DNA virus, in German patients. J Gen Virol 79:2761–2764, 1998
Niel C, de Oliveira JM, Ross RS, Gomes SA, Roggendorf M, Viazov S: High prevalence of TT virus infection in Brazilian blood donors.J Med Virol 57:259–263, 1999
Takayama S, Miura T, Matsuo S, Taki M, Sugii S: Prevalence and persistence of a novel DNA TT virus (TTV) infection in Japanese haemophiliacs. Br J Haematol 104:626–629, 1999
Hsieh SY, Wu YH, Ho YP, Tsao KC, Yeh CT, Liaw YF: High prevalence of TT virus infection in healthy children and adults and in patients with liver disease in Taiwan. J Clin Microbiol 37:1829–1831, 1999
Kao JH, ChenW, Hsiang SC, Chen PJ, LaiMY, Chen DS: Prevalence and implication of TT virus infection: minimal role in patients with non-A-E hepatitis in Taiwan. J Med Virol 59:307–312, 1999
Mushahwar IK: Recently discovered blood-borne viruses: Are they hepatitis viruses or merely endosymbionts? J Med Virol 62:399–404, 2000
Bowden S: New hepatitis viruses: contenders and pretenders. J Gastroenterol Hepatol 16:124–131, 2001
Tanaka Y, Primi D, Wang RY, et al: Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN virus) and its relationship to the TT virus family. J Infect Dis 183:359–367, 2001
Umemura T, Yeo AE, Sottini A, et al: SEN virus infection and its relationship to transfusion-associated hepatitis. Hepatology 33:1303–1311, 2001
Mukaide M, Mizokami M, Orito E, et al: Three different GB virus C/hepatitis G virus genotypes. Phylogenetic analysis and a genotyping assay based on restriction fragment length polymorphism.FEBS. Lett 407:51–58, 1997
Tacke M, Kiyosawa K, Stark K, et al: Detection of antibodies to a putative hepatitis G virus envelope protein. Lancet 349:318–320, 1997
Shibata M, Wang RY, Yoshiba M, Shih JW, Alter HJ, Mitamura K: The presence of a newly identified infectious agent (SEN virus) in 1184 Digestive Diseases and Sciences, Vol. 49, Nos. 7/8 (August 2004) SEN VIRUS INFECTION IN DONORS IN TAIWAN patients with liver diseases and in blood donors in Japan. J Infect Dis 184:400–404, 2001
Kobayashi N, Tanaka E, Umemura T, et al: Clinical significance of SEN virus infection in patients on maintenance haemodialysis.Nephrol Dial Transplant 18:348–352, 2003
Kao JH, ChenW, Chen PJ, LaiMY, Chen DS: Prevalence and Implication of a newly identified infectious agent (SEN virus) in Taiwan.J Infect Dis 185:389–392, 2002
Kao JH, Chen W, Chen PJ, Lai MY, Chen DS: SEN virus infection in patients with chronic hepatitis C: preferential coinfection with hepatitis C genotype 2a and no effect on response to therapy with interferon plus ribavirin. J Infect Dis 187:307–310, 2003
Umemura T, Alter HJ, Tanaka E, et al: Association between SEN virus infection and hepatitis C in Japan. J Infect Dis 184:1246–1251, 2001
Umemura T, Alter HJ, Tanaka E, et al: SEN virus: response to interferon alfa and influence on the severity and treatment response of coexistent hepatitis C. Hepatology 35:953–959, 2002
Wu JS, Lee HF, Hsiau HL, et al: Genotype distribution of hepatitis C virus infection in Taiwan. J Med Virol 44:74–79, 1994
Yu ML, Chuang WL, Chen SC, et al: The genotypes of hepatitis C virus in patients with chronic hepatitis C virus infection in southern Taiwan. Kaohsiung J Med Sci 12:605–612, 1996
Yu ML, Chuang WL, Chen SC et al: Changing prevalence of hepatitis C virus genotypes: molecular epidemiology and clinical implications in the hepatitis C virus hyperendemic areas and a tertiary referral center in Taiwan. J Med Virol 65:58–65, 2001</del>
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Dai, CY., Yu, ML., Lin, ZY. et al. Prevalence and Clinical Significance of SEN Virus Infection Among Volunteer Blood Donors in Southern Taiwan. Dig Dis Sci 49, 1181–1185 (2004). https://doi.org/10.1023/B:DDAS.0000037809.87654.73
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DOI: https://doi.org/10.1023/B:DDAS.0000037809.87654.73