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Integrins: Structure and Signaling

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Abstract

Integrins are cell surface transmembrane glycoproteins that function as adhesion receptors in cell–extracellular matrix interactions and link the matrix proteins to the cytoskeleton. The family of human integrins comprises 24 members, each of which is a heterodimer consisting of 1 of 18 α- and 1 of 8 β-subunits. Integrins play an important role in the cytoskeleton organization and in transduction of intracellular signals, regulating various processes such as proliferation, differentiation, apoptosis, and cell migration. This review summarizes current views on the structure of integrins, integrin associated proteins, and biochemical mechanisms underlying their signaling functions.

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REFERENCES

  1. Eble, J. A. (1997) in Molecular Biology Intelligence Unit. Integrin-Ligand Interaction (Eble, J. A., and Kunn, K., eds.) Chapman and Hall, New York, pp. 1-40.

    Google Scholar 

  2. Van der Flier, A., and Sonnenberg, A. (2001) Cell Tissue Res., 305, 285-298.

    Google Scholar 

  3. Hynes, R. O. (2002) Cell, 110, 673-687.

    Google Scholar 

  4. Giancotti, F. G. (1997) Cur. Opin. Cell Biol., 9, 691-700.

    Google Scholar 

  5. Mould, A. P., Askari, J. A., and Humphries, M. J. (2000) J. Biol. Chem., 275, 20324-20336.

    Google Scholar 

  6. Loster, K., Vossmeyer, D., Hofmann, W., Reutter, W., and Danker, K. (2001) Biochem. J., 356, 233-240.

    Google Scholar 

  7. Hood, J. D., and Cheresh, D. A. (2002) Nature Rev. Cancer, 2, 91-100.

    Google Scholar 

  8. Humphries, M. J. (2000) Biochem. Soc. Trans., 28, 311-339.

    Google Scholar 

  9. Oxvig, G., and Springer, T. A. (1998) Proc. Natl. Acad. Sci. USA, 95, 4870-4875.

    Google Scholar 

  10. Corbi, A. L., Garcia-Aguilar, J., and Springer, T. A. (1990) J. Biol. Chem., 265, 2782-2788.

    Google Scholar 

  11. Humphries, M. J., and Newham, P. (1998) Trends Cell Biol., 8, 78-83.

    Google Scholar 

  12. Ignatius, M. J., Large, T. H., Houde, M., Tawil, J. W., Barton, A., Esch, F., Carbonetto, S., and Reichardt, L. F. (1990) J. Cell. Biol., 111, 709-720.

    Google Scholar 

  13. Lee, O. J., Rieu, P., Arnaout, M. A., and Liddington, R. (1995) Cell, 80, 631-638.

    Google Scholar 

  14. Tuckwell, D. S., and Humphries, M. J. (1997) FEBS Lett., 400, 297-303.

    Google Scholar 

  15. Cierniewska-Ciestak, A., Cierniewski, C. S., Blecka, K., Papierak, M., Michalee, L., Zhang, L., Haas, T. A., and Plow, E. F. (2002) J. Biol. Chem., 277(10), 126-134.

    Google Scholar 

  16. Fleming, J. C., Pahl, H. K., Gonzalez, D. A., Smith, T. F., and Tenen, D. G. (1993) J. Immunol., 150, 480-490.

    Google Scholar 

  17. Shaw, L. M., Turner, C. E., and Mercurio, A. M. (1995) J. Biol. Chem., 270, 23648-23652.

    Google Scholar 

  18. Kassner, P. D., Alon, R., Springer, T. A., and Hemler, M. E. (1995) Mol. Biol. Cell., 6, 661-674.

    Google Scholar 

  19. Green, L. J., Mould, A. P., and Humphries, M. J. (1998) Int. J. Biochem. Cell Biol., 30, 179-184.

    Google Scholar 

  20. Sastry, S. K., and Horwitz, A. F. (1993) Curr. Opin. Cell. Biol., 5, 819-831.

    Google Scholar 

  21. Languino, L. R., and Ruoslahti, E. (1992) J. Biol. Chem., 267, 7116-7120.

    Google Scholar 

  22. Belkin, A. M., and Retta, S. F. (1998) J. Biol. Chem., 273, 15234-15240.

    Google Scholar 

  23. De Melker, A. A., and Sonnenberg, A. (1999) Bioessays, 21, 499-509.

    Google Scholar 

  24. Briesewitz, R., Kern, A., and Marcantonio, E. E. (1995) Mol. Biol. Cell, 4, 593-604.

    Google Scholar 

  25. Hughes, P. E., Diaz-Gonzalez, F., Leong, L., Wu, C., McDonald, J. A., Shattil, S. J., and Ginsberg, M. H. (1996) J. Biol. Chem., 271, 6571-6574.

    Google Scholar 

  26. Venter, J. C., Adams, M. D., Myers, F. W., Mural, R. J., Sutton, G. G., Smith, H. O., and Zhu, X. (2001) Science, 291, 1304-1351.

    Google Scholar 

  27. Plow, E. F., Haas, T. A., Zhang, L., Loftus, J., and Smith, J. W. (2000) J. Biol. Chem., 275, 21785-21788.

    Google Scholar 

  28. Hynes, R. O. (1992) Cell, 69, 11-25.

    Google Scholar 

  29. Springer, T. A. (1997) Proc. Natl. Acad. Sci. USA, 94, 65-72.

    Google Scholar 

  30. Xiong, J. P., Stehle, T., Diefenbach, B., Zhang, R., Dukker, R., Scott, D. L., Joachimiak, A., Goodman, S. L., and Arnaout, M. A. (2001) Science, 294, 339-345.

    Google Scholar 

  31. Springer, T. A. (2002) Curr. Opin. Struct. Biol., 12, 802-813.

    Google Scholar 

  32. Plantefaber, L. C., and Hynes, R. O. (1989) Cell, 56, 281-290.

    Google Scholar 

  33. Pierschbacher, M. D., and Ruoslahti, E. (1984) Nature, 309, 30-33.

    Google Scholar 

  34. Pfaff, M. (1997) in Molecular Biology Intelligence Unit. Integrin-Ligand Interaction (Eble, J. A., and Kunn, K., eds.) Chapman and Hall, New York, pp. 101-122.

    Google Scholar 

  35. Nista, A., Leonetti, C., Bernardini, G., Mattioni, M., and Santoni, A. (1997) Int. J. Cancer, 72, 133-141.

    Google Scholar 

  36. Matter, M. L., and Ruoslahti, E. (2001) J. Biol. Chem., 276, 27757-27763.

    Google Scholar 

  37. Pfaff, M., Gohring, W., Brown, J. C., and Timpl, R. (1994) Eur. J. Biochem., 225, 975-984.

    Google Scholar 

  38. Colognato-Pyke, H., O'Rear, J. J., Yamada, Y., Carbonetto, S., Cheng, Y. S., and Yurchenco, P. D. (1995) J. Biol. Chem., 270, 9398-9406.

    Google Scholar 

  39. George, E. L., Georges-Labouesse, E. N., Patel-King, R. S., Rayburn, H., and Hynes, R. O. (1993) Development, 119, 1079-1091.

    Google Scholar 

  40. Hynes, R. O. (1996) Dev. Biol., 180, 402-412.

    Google Scholar 

  41. Yang, J. T., Rayburn, H., and Hynes, R. O. (1993) Development, 119, 1093-1105.

    Google Scholar 

  42. Yang, J. T., Bader, B. L., Kreidberg, J. A., Ullman-Cullere, M., Trevithick, J. E., and Hynes, R. O. (1999) Dev. Biol., 215, 264-277.

    Google Scholar 

  43. Arcangelis, A. D., and Georges-Labouesse, E. (2000) Trends Genet., 16, 389-395.

    Google Scholar 

  44. Pozzi, A., Wary, K. K., Giancotti, F. G., and Gardner, H. A. (1998) J. Cell Biol., 142, 587-594.

    Google Scholar 

  45. Mayer, U., Saher, G., Fassler, R., Bornemann, A., Echtermeyer, F., von der Mark, H., Miosge, N., Poschl, E., and von der Mark, K. (1997) Nat. Genet., 17, 318-323.

    Google Scholar 

  46. Miosge, N., Klenczar, C., Herken, R., Willem, M., and Mayer, U. (1999) Lab. Invest., 79, 1591-1599.

    Google Scholar 

  47. Hayashi, Y. K., Chou, F. L., Engvall, E., Ogawa, M., Matsuda, C., Hirabayashi, S., Yokochi, K., Ziober, B. L., Kramer, R. H., Kaufman, S. J., Ozawa, E., Goto, Y., Nonaka, I., Tsukahara, T., Wang, J. Z., Hoffman, E. P., and Arahata, K. (1998) Nat. Genet., 19, 94-97.

    Google Scholar 

  48. Anton, E. S., Kreidberg, J. A., and Rakic, P. (1999) Neuron, 22, 277-289.

    Google Scholar 

  49. Kreidberg, J. A., Donovan, M. J., Goldstein, S. L., Rennke, H., Shepherd, K., Jones, R. C., and Jaenisch, R. (1996) Development, 122, 3537-3547.

    Google Scholar 

  50. DiPersio, C. M., Hodivala-Dilke, K. M., Jaenisch, R., Kreidberg, J. A., and Hynes, R. O. (1997) J. Cell Biol., 137, 729-742.

    Google Scholar 

  51. Gorski, J. P., and Olsen, B. R. (1998) Curr. Opin. Cell. Biol., 10, 586-593.

    Google Scholar 

  52. Georges-Labouesse, E., Messaddeq, N., Yehia, G., Cadalbert, L., Dierich, A., and le Meur, M. (1996) Nat. Genet., 13, 370-373.

    Google Scholar 

  53. Georges-Labouesse, E., Mark, M., Messaddeq, N., and Gansmuller, A. (1998) Curr. Biol., 8, 983-986.

    Google Scholar 

  54. Hotchin, N. A., Gandarillas, A., and Watt, F. M. (1995) J. Cell Biol., 128, 1209-1219.

    Google Scholar 

  55. Bagutti, C., Wobus, A. M., Fassler, R., and Watt, F. M. (1996) Dev. Biol., 179, 184-196.

    Google Scholar 

  56. Sastry, S. K., Lakonishok, M., Thomas, D. A., Muschler, J., and Horwitz, A. (1996) J. Cell Biol., 133, 169-184.

    Google Scholar 

  57. Howe, A., Aplin, A. E., Alahari, S. K., and Juliano, R. L. (1998) Curr. Opin. Cell. Biol., 10, 220-231.

    Google Scholar 

  58. Assoian, R. K., and Schwartz, M. A. (2001) Curr. Opin. Genet. Dev., 11, 48-53.

    Google Scholar 

  59. Vasil'ev, Yu. M., and Gelfand, I. M. (1981) in Interaction of Normal and Neoplastic Cells with Their Environment [in Russian], Nauka, Moscow.

    Google Scholar 

  60. Schwartz, M. A., Lechene, C., and Ingber, D. E. (1991) Proc. Natl. Acad. Sci. USA, 88, 7849-7853.

    Google Scholar 

  61. Lin, T. H., Chen, O., Howe, A., and Juliano, R. L. (1997) J. Cell. Biol., 272, 8849-8852.

    Google Scholar 

  62. Vuori, K. (1998) J. Membr. Biol., 165, 191-199.

    Google Scholar 

  63. Kopnin, B. P. (2000) Biochemistry (Moscow), 65, 2-27.

    Google Scholar 

  64. Ilic, D., Damsky, C. H., and Yamamoto, T. (1997) J. Cell Sci., 110, 401-407.

    Google Scholar 

  65. Assoian, R. K. (1997) J. Cell. Biol., 136, 1-4.

    Google Scholar 

  66. Guadagno, T. M., Ohtsubo, M., Roberts, J. M., and Assoian, R. K. (1993) Science, 262, 1572-1575.

    Google Scholar 

  67. Zhu, X., Ohtsubo, M., Bohmer, J., Roberts, J. M., and Assoian, R. K. (1997) J. Cell. Biol., 133, 391-403.

    Google Scholar 

  68. Resnitsky, D. (1997) J. Cell. Biol., 17, 5640-5647.

    Google Scholar 

  69. Howe, A. K., Aplin, A. E., and Juliano, R. L. (2002) Curr. Opin. Genet. Dev., 12, 30-35.

    Google Scholar 

  70. Craig, S. W., and Johnson, R. P. (1996) Curr. Opin. Cell. Biol., 8, 74-85.

    Google Scholar 

  71. Grenz, H., Carbonetto, S., and Goodman, S. L. (1993) J. Cell Sci., 105, 739-751.

    Google Scholar 

  72. Miyamoto, S., Teramoto, K. M., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K., and Yamada, K. M. (1995) J. Cell. Biol., 131, 791-805.

    Google Scholar 

  73. Liu, S., Calderwood, D. A., and Ginsberg, M. H. (2000) J. Cell. Sci., 113, 3563-3571.

    Google Scholar 

  74. Burridge, K., and Chrzanowska-Wodnicka, M. (1996) Annu. Rev. Cell Dev. Biol., 12, 463-519.

    Google Scholar 

  75. Schoenwaelder, S. M., and Burridge, K. (1999) Curr. Opin. Cell. Biol., 11, 274-286.

    Google Scholar 

  76. Boudreau, N. J., and Jones, P. L. (1999) Biochem. J., 339, 481-488.

    Google Scholar 

  77. Mueller, S. C., Kelly, T., Dai, M. Z., Dai, H. N., and Chen, W. T. (1989) J. Cell Biol., 109, 3455-3464.

    Google Scholar 

  78. Stromblad, S., Becker, J. C., Yebra, M., Brooks, P. C., and Cheresh, D. A. (1996) J. Clin. Invest., 98, 426-433.

    Google Scholar 

  79. Kozlova, N. I., Morozevich, G. E., Chubukina, A. N., and Berman, A. E. (2001) Oncogene, 20, 4710-4717.

    Google Scholar 

  80. Zamir, E., Katz, M., Posen, Y., Erez, N., Yamada, K. M., Katz, B. Z., Lin, S., Lin, D. C., Bershadsky, A., Kam, Z., and Geiger, B. (2000) Nature Cell. Biol., 2, 191-196.

    Google Scholar 

  81. Katz, B. Z., Zamir, E., Bershadsky, A., Kam, Z., Yamada, K. M., and Geiger, B. (2000) Mol. Biol. Cell, 11, 104-1060.

    Google Scholar 

  82. Glogauer, M., Arora, P., Chou, D., Janmey, P. A., Downey, G. P., and McCulloch, C. A. (1998) J. Biol. Chem., 273, 1689-1698.

    Google Scholar 

  83. Schwartz, M. A., and Shattil, S. J. (2000) Trends Biochem. Sci., 25, 388-391.

    Google Scholar 

  84. Marcantonio, E. E., Guan, J.-L., Trevithick, J. E., and Hynes, R. O. (1990) Cell Regul., 1, 597-604.

    Google Scholar 

  85. O'Toole, T. E., Katagiri, Y., Faull, R. J., Peter, K., Tamura, R. N., Quaranta, V., Loftus, J. C., Shattil, S. J., and Ginsberg, M. H. (1994) J. Cell. Biol., 124, 1047-1059.

    Google Scholar 

  86. Hughes, P. E., and Pfaff, M. (1998) Trends Cell Biol., 8, 359-364.

    Google Scholar 

  87. Lewis, J. M., Cheresh, D. A., and Schwartz, M. A. (1996) J. Cell Biol., 134, 1323-1332.

    Google Scholar 

  88. Akiyama, S. K., Yamada S. S., Yamada, K. M., and LaFlamme, S. E. (1994) J. Biol. Chem., 269, 15961-15964.

    Google Scholar 

  89. Calderwood, D. A., Zent, R., Grant, R., Rees, D. J., Hynes, R. O., and Ginsberg, M. H. (1999) J. Biol. Chem., 274, 28071-28074.

    Google Scholar 

  90. Priddle, H., Hemmings, L., Monkley, S., Woods, A., Patel, B., Sutton, D., Dunn, G. A., Zicha, D., and Critchley, D. R. (1998) J. Cell. Biol., 142, 1121-1133.

    Google Scholar 

  91. Martel, V., Vignoud, L., Dupe, S., Frachet, P., Block, M. R., and Albiges-Rizo, C. (2000) J. Cell. Sci., 113, 1951-1961.

    Google Scholar 

  92. Goldmann, W. H. (2000) Biochem. Biophys. Res. Commun., 271, 553-557.

    Google Scholar 

  93. Retta, S. F., Balzac, F., Ferraris, P., Belkin, A. M., Fassler, R., Humphries, M. J., De Leo, G., Silengo, L., and Tarone, G. (1998) Mol. Biol. Cell, 9, 715-731.

    Google Scholar 

  94. Loo, D. T., Kanner, S. B., and Aruffo, A. (1998) J. Biol. Chem., 273, 23304-23312.

    Google Scholar 

  95. Liu, S., Kiosses, W. B., Rose, D. M., Slepak, M., Salgia, R., Griffin, J. D., Turner, C. E., Schwartz, M. A., and Ginsberg, M. H. (2002) J. Biol. Chem., 277, 20887-20894.

    Google Scholar 

  96. Hemler, M. E., Kassner, P. D., and Chan, B. M. (1992) Cold Spring Harbor Symp. Quant. Biol., 57, 213-220.

    Google Scholar 

  97. Kassner, P. D., Alon, R., Springer, T. A., and Hemler, M. E. (1995) Mol. Biol. Cell, 6, 661-674.

    Google Scholar 

  98. Liu, S., Thomas, S. M., Woodside, D. G., Rose, D. M., Kiosses, W. B., Pfaff, M., and Ginsberg, M. H. (1999) Nature, 402, 676-681.

    Google Scholar 

  99. Briesewitz, R., Kern, A., and Marcantonio, E. E. (1993) Mol. Biol. Cell, 4, 593-604.

    Google Scholar 

  100. Vinogradova, O., Haas, T., Plow, E. F., and Qin, J. (2000) Proc. Natl. Acad. Sci. USA, 97, 1450-1455.

    Google Scholar 

  101. Bellis, S. L., Perrotta, J. A., Curtis, M. S., and Turner, C. E. (1997) Biochem. J., 325, 375-381.

    Google Scholar 

  102. Malik, R. K., and Parsons, J. T. (1996) J. Biol. Chem., 271, 29785-29791.

    Google Scholar 

  103. Schaller, M. D., Otey, C. A., Hildebrand, J. D., and Parsons, J. T. (1995) J. Cell. Biol., 130, 1181-1187.

    Google Scholar 

  104. Tahiliani, P. D., Singh, L., Auer, K. L., and LaFlamme, S. E. (1997) J. Biol. Chem., 272, 7892-7898.

    Google Scholar 

  105. Assoian, R. K., and Schwartz, M. A. (2001) Curr. Opin. Genet. Dev., 11, 48-53.

    Google Scholar 

  106. Schlaepfer, D. D., and Hunter, T. (1998) Trends Cell Biol., 8, 151-157.

    Google Scholar 

  107. Tatosyan, A. G., and Mizenina, O. A. (2000) Biochemistry (Moscow), 65, 49-58.

    Google Scholar 

  108. Etienne-Manneville, S., and Hall, A. (2002) Nature, 420, 629-635.

    Google Scholar 

  109. Caron, E. (2003) Nature Cell Biol., 5, 185-187.

    Google Scholar 

  110. Li, L., Okura, M., and Imamoto, A. (2002) Mol. Cell Biol., 22, 1203-1217.

    Google Scholar 

  111. Ridley, A. J. (2001) J. Cell Sci., 114, 2713-2722.

    Google Scholar 

  112. Cheresh, D. A., Leng, J., and Klemke, R. I. (1999) J. Cell Biol., 146, 110-1116.

    Google Scholar 

  113. Arthur, W. T., Petch, L. A., and Burridge, K. (2000) Curr. Biol., 10, 719-722.

    Google Scholar 

  114. Arthur, W. T., and Burridge, K. (2000) Mol. Biol., 12, 2711-2720.

    Google Scholar 

  115. Nimnual, A. S., Taylor, L. J., and Bar-Sagi, D. (2003) Nature Cell. Biol., 5, 236-241.

    Google Scholar 

  116. Bokoch, G. M., and Diebold, B. A. (2002) Blood, 100, 2692-2696.

    Google Scholar 

  117. Rottner, K., Hall, A., and Small, J. V. (1999) Curr. Biol., 9, 640-648.

    Google Scholar 

  118. Cox, E. A., Sastry, S. K., and Huttenlocher, A. (2001) Mol. Biol. Cell, 12, 265-277.

    Google Scholar 

  119. Woods, A., and Couchman, J. R. (1992) J. Cell Sci., 101, 277-290.

    Google Scholar 

  120. Vuori, K., and Ruoslahti, E. (1993) J. Biol. Chem., 268, 21459-21462.

    Google Scholar 

  121. Zhang, X. A., Bontrager, A. L., and Hemler, M. E. (2001) J. Biol. Chem., 276, 25005-25013.

    Google Scholar 

  122. Ng, T., Shima, D., Squire, A., Bastiaens, P. I., Gschmeissner, S., Humphries, M. J., and Parker, P. J. (1999) EMBO J., 18, 3909-3923.

    Google Scholar 

  123. Rabinovvitz, I., Toker, A., and Mercurio, A. M. (1999) J. Cell Biol., 146, 1147-1160.

    Google Scholar 

  124. Howe, A. K. (2000) J. Biol. Chem., 276, 14541-14544.

    Google Scholar 

  125. Del Pozo, M. A., Price, L. S., Alderson, N. B., Ren, X.-D., and Schwartz, M. A. (2000) EMBO J., 19, 2008-2014.

    Google Scholar 

  126. Sanders, L. C., Matsumura, F., Bokoch, G. M., and Lanerolle, P. (1999) Science, 283, 2083-2085.

    Google Scholar 

  127. Frisch, S. M., and Screaton, R. A. (2001) Curr. Opin. Cell. Biol., 13, 555-562.

    Google Scholar 

  128. Vazquez, F., and Sellers, W. R. (2000) Biochim. Biophys. Acta, 1470, M21-M35.

    Google Scholar 

  129. Krasilnikov, M. A. (2000) Biochemistry (Moscow), 65, 59-67.

    Google Scholar 

  130. Leevers, S. J., Vanhaesebroeck, B., and Waterfield, M. D. (1999) Curr. Opin. Cell. Biol., 11, 219-225.

    Google Scholar 

  131. Adelsman, M. A., McCarthy, J. B., and Shimizu, Y. (1999) Mol. Biol. Cell, 10, 2861-2878.

    Google Scholar 

  132. Dedhar, S., Williams, B., and Hannigan, G. (1999) Trends Cell Biol., 9, 319-323.

    Google Scholar 

  133. Dedhar, S. (2000) Curr. Opin. Cell. Biol., 12, 250-256.

    Google Scholar 

  134. Wu, C., and Dedhar, S. (2001) J. Cell Biol., 155, 505-510.

    Google Scholar 

  135. Tu, Y., Li, F., and Wu, C. (1998) Mol. Biol. Cell, 9, 3367-3382.

    Google Scholar 

  136. Delcommenne, M., Tan, C., Gray, V., Ruel, L., Woodgett, J., and Dedhar, S. (1998) Proc. Natl. Acad. Sci. USA, 95, 11211-11216.

    Google Scholar 

  137. Persad, S., Attwell, S., Gray, V., Delcommenne, M., Troussard, A., Sanghera, J., and Dedhar, S. (2000) Proc. Natl. Acad. Sci. USA, 97, 3207-3212.

    Google Scholar 

  138. Novak, A., Hsu, S.-C., Leung-Hagesteijn, C., Radeva, G., Papkoff, J., Montesano, R., Roskelley, C., Grosschedl, R., and Dedhar, S. (1998) Proc. Natl. Acad. Sci. USA, 95, 4374-4379.

    Google Scholar 

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  1. Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Orekchovich Institute of Biomedical Chemistry, Moscow, 119121, Russia

    A. E. Berman, N. I. Kozlova & G. E. Morozevich

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Berman, A.E., Kozlova, N.I. & Morozevich, G.E. Integrins: Structure and Signaling. Biochemistry (Moscow) 68, 1284–1299 (2003). https://doi.org/10.1023/B:BIRY.0000011649.03634.74

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