Abstract
A single-step acylation of rutin and naringin, catalyzed by immobilized Candida antarctica lipase B in 2-methyl-2-butanol, occurred preferentially on the primary hydroxyl group. Using palmitic methyl ester as acyl donor, the acylation rate of naringin was 10-fold higher than that of rutin. Under optimal conditions, i.e. a molar ratio acyl donor/naringin of 7:1 and 200 mbar, 92% naringin was acylated.
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Passicos, E., Santarelli, X. & Coulon, D. Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure. Biotechnology Letters 26, 1073–1076 (2004). https://doi.org/10.1023/B:BILE.0000032967.23282.15
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DOI: https://doi.org/10.1023/B:BILE.0000032967.23282.15