Abstract
The effects of NO-generating compounds on the tumoritoxic effect of doxorubicin was evaluated by changes in DNA synthesis and apoptotic death of Ehrlich adenocarcinoma cells in vitro. NO donors significantly inhibited the cytotoxic effect of doxorubicin, which manifested in activation of DNA synthesis and decreased induction of apoptosis. Presumably, NO acts a factor protecting tumor cell DNA from the damaging effect of doxorubicin.
Similar content being viewed by others
REFERENCES
V. I. Levina, O. V. Azizov, A. P. Arzamastsev, et al., Vopr. Biol. Med. Farm. Khim., No. 1, 47-49 (2001).
S. V. Lutsenko, N. B. Fel'dman, S. G. Gumanov, et al., Ibid., No. 2, 3-9 (2001).
V. P. Reutov, E. G. Sorokina, V. E. Okhotin, et al., Cyclic Transformations of Nitrogen Oxide in Mammals [in Russian], Moscow (1998).
D. S. Lind, M. I. Kontaridis, P. D. Edwards, et al., J. Surg. Res., 69, 238-287 (1997).
N. Nakaya, S. W. Lowe, Y. Taya, et al., Oncogene, 19, No. 54, 6369-6375 (2000).
S. N. Orlov, T. V. Dam, J. Tremblay, and P. Hamet, Biochem. Biophys. Res. Commun., 221, No. 3, 708-715 (1996).
W. Xu, L. Liu, G. C. Smith, et al., Nat. Cell. Biol., 2, No. 6, 339-345 (2000).
F. Yang, A. von Knethen, and B. Brune, J. Leukoc. Biol., 68, No. 6, 916-922 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kondakova, I.V., Zagrebelnaya, G.V. & Choinzonov, E.T. NO-Generating Compounds Modify Tumoritoxic Effect of Doxorubicin. Bulletin of Experimental Biology and Medicine 137, 585–587 (2004). https://doi.org/10.1023/B:BEBM.0000042719.10494.3f
Issue Date:
DOI: https://doi.org/10.1023/B:BEBM.0000042719.10494.3f