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Changes in the Steady-State Potential in Rats with Focal Cerebral Ischemia Receiving Cyclopentyladenosine

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Abstract

Brain function and neuroprotective activity of cyclopentyladenosine in rats with focal cerebral ischemia were evaluated by recording the steady-state potential. Cerebral ischemia was modeled by intravasal occlusion of the left internal carotid and middle cerebral arteries and bilateral occlusion of the common carotid arteries. Recording of the steady-state brain potential during experimental ischemia allowed identifying the development of ischemic depolarization by a negative potential shift. Changes in the steady-state potential after cyclopentyladenosine administration reflected delayed development of ischemic depolarization in the nervous tissue. Cyclopentyladenosine holds much promise for the protection of nerve cells from ischemic injury.

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Authors and Affiliations

  1. Department of Pharmacology, Irkutsk State Medical University, Russia

    G. Z. Sufianova, S. E. Murik, L. A. Usov, A. A. Sufianov, A. G. Shapkin & M. V. Taborov

  2. Department of Childhood Neurosurgery, Irkutsk Regional Children's Hospital, Russia

    G. Z. Sufianova, S. E. Murik, L. A. Usov, A. A. Sufianov, A. G. Shapkin & M. V. Taborov

Authors
  1. G. Z. Sufianova
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  2. S. E. Murik
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  3. L. A. Usov
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  4. A. A. Sufianov
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  5. A. G. Shapkin
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  6. M. V. Taborov
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Sufianova, G.Z., Murik, S.E., Usov, L.A. et al. Changes in the Steady-State Potential in Rats with Focal Cerebral Ischemia Receiving Cyclopentyladenosine. Bulletin of Experimental Biology and Medicine 136, 576–578 (2003). https://doi.org/10.1023/B:BEBM.0000020208.53694.20

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  • DOI: https://doi.org/10.1023/B:BEBM.0000020208.53694.20

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