Abstract
Early, middle and late latency somatosensory evoked potentials (SEPs) elicited by cutaneous electrical stimulation (painful vs. non-painful) of right and left hands were recorded. The aims were to study (1) if lifelong use of dominant right hand would result in different SEP topographies compared to non-dominant left hand stimulation, (2) if painful and non-painful stimuli resulted in different SEP activation patterns for the different latency components and (3) if these results were consistent between two areas of the hand. Electrical stimuli were applied cutaneously above the thenar and hypothenar muscles of the left and right hand. A two-way repeated measures ANOVA was used to test the effects of laterality and intensity for a given peak amplitude and latency. Statistical results yielded no significant difference in peak amplitude for either thenar and hypothenar between the two hands. In contrast, a significant difference in amplitude was observed for 6 components for each stimulus location when the two intensities were compared. These components were found at early, middle and late latencies. No significant latency shift was observed between the two hands. Only the P30 component showed a significant latency shift for both locations with the painful condition having the shorter latency. Thus, life-long use of the dominant hand does not generate detectable changes in cortical evoked activity to sensory input from the skin above thenar and hypothenar muscles. Several SEP components across the time course (0-400 ms) showed increased amplitude when the stimulus was increased from non-painful to painful intensity.
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Arendt-Nielsen, L. Characteristics, detection, and modulation of laser-evoked vertex potentials. Acta. Anaesthesiol. Scand. Suppl., 1994, 101: 7-44.
Beydoun, A., Morrow, T.J., Shen, J.F. and Casey, K.L. Variability of laser-evoked potentials: attention, arousal and lateralized differences. Electroencephalogr. Clin. Neurophysiol., 1993, 88(3): 173-181.
Birbaumer, N., Lutzenberger, W., Montoya, P., Larbig, W., Unertl, K., Topfner, S., Grodd, W., Taub, E. and Flor, H. Effects of regional anesthesia on phantom limb pain are mirrored in changes in cortical reorganization. J. Neurosci., 1997, 17(14): 5503-5508.
Brennum, J. and Jensen, T.S. Relationship between vertex potentials and magnitude of pre-pain and pain sensations evoked by electrical skin stimuli. Electroencephalogr. Clin. Neurophysiol., 1992, 82(5): 387-390.
Bromm, B. and Scharein, E. Principal component analysis of pain-related cerebral potentials to mechanical and electrical stimulation in man. Electroencephalogr. Clin. Neurophysiol., 1982, 53(1): 94-103.
Bromm, B. and Chen, A.C. Brain electrical source analysis of laser evoked potentials in response to painful trigeminal nerve stimulation. Electroencephalogr. Clin. Neurophysiol., 1995, 95(1): 14-26.
Bromm, B. and Lorenz, J. Neurophysiological evaluation of pain. Electroencephalogr. Clin. Neurophysiol., 1998, 107(4): 227-253.
Buchsbaum, M.S., Davis, G.C., Coppola, R. and Naber, D. Opiate pharmacology and individual differences. I. Psychophysical pain measurements. Pain, 1981, 10(3): 357-366.
Buchsbaum, M.S., Davis, G.C., Coppola, R. and Naber, D. Opiate pharmacology and individual differences. II. Somatosensory evoked potentials. Pain, 1981, 10(3): 367-377.
Casey, K.L., Minoshima, S., Berger, K.L., Koeppe, R.A., Morrow, T.J. and Frey, K.A. Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli. J. Neurophysiol., 1994, 71(2): 802-807.
Chen, A.C.N., Chapman, C.R. and Harkins, S.W. Brain evoked potentials are functional correlates of induced pain in man. Pain, 1979, 6(3): 365-374.
Chen, A.C.N., Plaghki, L., Arendt-Nielsen, L. and Chen et al. Laser-evoked potentials in human pain: I. Use and possible misuse. Pain Forum, 1998, 7(4): 174-184.
Chen, A.C.N., Niddam, D., Le Pera, D. and Arendt-Nielsen, L. The earliest brain dynamic activation (frontal Fz/N30 differentiating the noxious from innocuous galvanic stimulation, n. median, in man. NeuroImage, 1999, 9: 818.
Cheron, G. and Borenstein, S. Gating of the early components of the frontal and parietal somatosensory evoked potentials in different sensory-motor interference modalities. Electroencephalogr. Clin. Neurophysiol., 1991, 80(6): 522-530.
Cohen, L.G. and Starr, A. Localization, timing and specificity of gating of somatosensory evoked potentials during active movement in man. Brain, 1987, 110 (Pt 2): 451-467.
Cohen, L.G., Ziemann, U., Chen, R., Classen, J., Hallett, M., Gerloff, C. and Butefisch, C. Studies of neuroplasticity with transcranial magnetic stimulation. J. Clin. Neurophysiol., 1998, 15(4): 305-324.
Davis, K.D., Kwan, C.L., Crawley, A.P. and Mikulis, D.J. Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli. J. Neurophysiol., 1998, 80(3): 1533-1546.
Dowman, R. SEP topographies elicited by innocuous and noxious sural nerve stimulation. II. Effects of stimulus intensity on topographic pattern and amplitude. Electroencephalogr. Clin. Neurophysiol., 1994, 92(4): 303-315.
Elbert, T. and Flor, H. Magnetoencephalographic investigations of cortical reorganization in humans. Electroencephalogr. Clin. Neurophysiol. Suppl., 1999, 49: 284-291.
Gandevia, S.C. and Burke, D. Projection of thenar muscle afferents to frontal and parietal cortex of human subjects. Electroencephalogr. Clin. Neurophysiol., 1990, 77(5): 353-361.
Garcia Larrea, L., Bastuji, H. and Mauguiere, F. Unmasking of cortical SEP components by changes in stimulus rate: a topographic study. Electroencephalogr. Clin. Neurophysiol., 1992, 84(1): 71-83.
Hari, R., Hamalainen, M., Kaukoranta, E., Reinikainen, K. and Teszner, D. Neuromagnetic responses from the second somatosensory cortex. Acta. Neurol. Scand., 1983,68(4): 207-212.
Huttunen, J. Effects of stimulus intensity on frontal, central and parietal somatosensory evoked potentials after median nerve stimulation. Electromyogr. Clin. Neurophysiol., 1995, 35(4): 217-223.
Hamalainen, H., Kekoni, J., Sams, M., Reinikainen, K. and Naatanen, R. Human somatosensory evoked potentials to mechanical pulses and vibration: contributions of SI and SII somatosensory cortices to P50 and P100 components. Electroencephalogr. Clin. Neurophysiol., 1990, 75(2): 13-21.
Kaas, J.H. and Florence, S.L. Mechanisms of reorganization in sensory systems of primates after periferal nerve injury. In: H.J. Freund, B.A. Sabel and O.W. Witte (Eds.), Brain Plasticity. Advances in Neurology, 1997, 73:147-155.
Kany, C. and Treede, R.D. Median and tibial nerve somatosensory evoked potentials: middle-latency components from the vicinity of the secondary somatosensory cortex in humans. Electroencephalogr. Clin. Neurophysiol., 1997, 104(5): 402-410.
Magerl, W., Ali, Z., Ellrich, J., Meyer, R.A. and Treede, R.D. C-and A delta-fiber components of heat-evoked cerebral potentials in healthy human subjects. Pain, 1999, 82(2): 127-137.
Pearce, A.J., Thickbroom, G.W., Byrnes, M.L. and Mastaglia, F.L. Functional reorganisation of the corticomotor projection to the hand in skilled racquet players. Exp. Brain Res., 2000, 130(2): 238-243.
Talbot, J.D., Marrett, S., Evans, A.C., Meyer, E., Bushnell, M.C. and Duncan, G.H. Multiple representations of pain in human cerebral cortex. Science, 1991, 15: 251(4999): 1355-1358.
Tomberg, C., Desmedt, J.E., Ozaki, I., Nguyen, T.H. and Chalklin, V. Mapping somatosensory evoked potentials to finger stimulation at intervals of 450 to 4000 msec and the issue of habituation when assessing early cognitive components. Electroencephalogr. Clin. Neurophysiol., 1989, 74(5): 347-358.
Treede, R.D., Kief, S., Holzer, T. and Bromm, B. Late somatosensory evoked cerebral potentials inresponse to cutaneous heat. Electroencephalogr. Clin. Neurophysiol., 1988, 70(5): 429-441.
Tsuji, S., Luders, H., Dinner, D.S., Lesser, R.P. and Klem, G. Effect of stimulus intensity on subcortical and cortical somatosensory evoked potentials by posterior tibial nerve stimulation. Electroencephalogr. Clin. Neurophysiol., 1984, 59(3): 229-237.
Valeriani, M., Rambaud, L. and Mauguière, F. Scalp topography and dipolar source modelling of potentials evoked by CO2 laser stimulation of the hand. Electroencephalogr. Clin. Neurophysiol., 1996, 100: 343-353.
Valeriani, M., Restuccia, D., Barba, C., Tonali, P. and Mauguiere, F. Central scalp projection of the N30 SEP source activity after median nerve stimulation. Muscle Nerve, 2000, 23(3): 353-360.
Waberski, T.D., Buchner, H., Perkuhn, M., Gobbele, R., Wagner, M., Kucker, W. and Silny, J. N30 and the effect of explorative finger movements: a model of the contribution of the motor cortex to early somatosensory potentials. Clin. Neurophysiol., 1999, 110(9): 1589-1600.
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Niddam, D.M., Arendt-Nielsen, L. & Chen, A.C. Cerebral Dynamics of SEPs to Non-Painful and Painful Cutaneous Electrical Stimulation of the Thenar and Hypothenar. Brain Topogr 13, 105–114 (2000). https://doi.org/10.1023/A:1026655001804
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DOI: https://doi.org/10.1023/A:1026655001804