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Role of Phosphorylation of Myosin- and Actin-Binding Proteins in Thrombin-Induced Permeability of Endothelial Cells

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Abstract

The thrombin-induced dysfunction of the barrier function of the blood vessel endothelium, which manifests itself in increased permeability, is largely mediated via the initiation of specific receptors that trigger multiple signaling cascades, including the activation of some protein kinases and the phosphorylation of their cytoskeletal targets. The role of the phosphorylation of myosin and actin-binding proteins in the thrombin-induced permeability of the endothelium and possible mechanisms of the regulation of the endothelium barrier function are discussed.

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  1. Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA

    T. Borbiev, J. G. N. Garcia & A. D. Verin

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Borbiev, T., Garcia, J.G.N. & Verin, A.D. Role of Phosphorylation of Myosin- and Actin-Binding Proteins in Thrombin-Induced Permeability of Endothelial Cells. Russian Journal of Bioorganic Chemistry 29, 464–470 (2003). https://doi.org/10.1023/A:1026057727168

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