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Structural and Functional Peculiarities of Homologous Domains of Angiotensin-Converting Enzyme

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Abstract

Somatic angiotensin-converting enzyme (ACE) consists of two homologous domains, each of them containing an active site. Differences in substrate specificities and affinity to inhibitors of the active sites of the two domains of bovine ACE are described. The ACE domains demonstrate different thermostability, and the reasons for this difference are analyzed. A structural model of the ACE domains is suggested, which allows us to reveal the structural subdomain important for the protein stability and localize the hydrophobic and carbohydrate-binding sites.

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Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, Vorob'evy gory, Moscow, 119992, Russia

    S. V. Voronov, P. V. Binevski, N. A. Zueva, V. A. Palyulin, I. I. Baskin, M. A. Orlova & O. A. Kost

Authors
  1. S. V. Voronov
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  2. P. V. Binevski
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  3. N. A. Zueva
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  4. V. A. Palyulin
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  5. I. I. Baskin
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  6. M. A. Orlova
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  7. O. A. Kost
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Voronov, S.V., Binevski, P.V., Zueva, N.A. et al. Structural and Functional Peculiarities of Homologous Domains of Angiotensin-Converting Enzyme. Russian Journal of Bioorganic Chemistry 29, 426–433 (2003). https://doi.org/10.1023/A:1026045324442

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