Abstract
The widespread occurrence of high inorganic arsenic in natural waters is attributed to human carcinogen and is identified as a major global public health issue. The scale of the problem in terms of population exposure (36 million) and geographical area coverage (173 × 103 Km2) to high arsenic contaminated groundwater (50–3200 μgL−1) compared to the National drinking water standard (50 μgL−1) and WHO recommended provisional limit (10 μgL−1) is greatest in the Holocene alluvium and deltaic aquifers of the Bengal Delta Plain (Bangladesh and West Bengal, India). This large-scale 'natural' high arsenic groundwater poses a great threat to human health via drinking water. Mobilization, metabolism and mitigation issues of high arsenic groundwater are complex and need holistic approach for sustainable development of the resource. Mobilization depends on the redox geo-chemistry of arsenic that plays a vital role in the release and subsequent transport of arsenic in groundwater. Metabolism narrates the biological response vis-à-vis clinical manifestations of arsenic due to various chemical and biological factors. Mitigation includes alternative source for safe drinking water supply. Drinking water quality regulatory standards as well as guidelines are yet to cover risk assessments for such metal toxicity. Lowering of the ingested inorganic arsenic level and introduction of newer treatment options (implementation of laterite, the natural material) to ensure safe water supply (arsenic free and/or low arsenic within permissible limit) are the urgent need to safe guard the mass arsenic poisoning and internal arsenic related health problems.
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Smedley PL, Kinniburgh DG: A review of the source, behaviour and distribution of arsenic in natural waters. Appl Geochem 17: 517-568, 2002
RGNDWM: Ministry of Rural Water and Development. Phase-II report executed by University of Kalyani, Kalyani, Nadia, West Bengal, India, 2001
CGWB: High Incidence of Arsenic in Groundwater in West Bengal. Central Groundwater Board, India, Ministry of Water Resources, Government of India, 1999
BGS, DPHE: Arsenic contamination of groundwater in Bangladesh. In: D.G. Kinniburgh, P.L. Smedley (eds). British Geological Survey (Technical Report, WC/00/19. 4 Volumes). British Geological Survey, Keyworth, 2001
WHO: Guidelines for Drinking-water Quality, Addendum to Volume 1: Recommendations. Geneva, 1998
Vahter M: Methylation of inorganic arsenic in different mammalian species and population groups. Sci Prog 82: 69-88, 1999b
National Research Council: Arsenic in Drinking Water. National Academy of Sciences, Washington DC, 2001
Bhattacharyya R: Removal of arsenic from groundwater and safe drinking water supply. Ph.D. thesis, University of Kalyani, 2002
Bhattacharya P, Chatterjee D, Jacks G: Occurrence of arsenic-contaminated groundwater in Alluvial Aquifers from Delta Plains, Eastern India: Options for safe drinking water supply. J Wat REs Dev 13: 79-92, 1997
McArthur JM, Ravenscroft P, Safiulla S, Thirlwall MF: Arsenic in groundwater: Testing pollution mechanisms for sedimentary aquifers in Bangladesh. Water Res Research 37: 109-117, 2001
National Research Council: Arsenic in drinking water. National Academy of Sciences, Washington DC, 1999
Edmonds JS, Shibata Y, Francesconi KA, Rippingale RJ, Moritaet M: Arsenic transformations in short marine food chains studied by HPLC-ICP MS. Appl Organomet Chem 11: 281-287, 1997
Vahter M: Species differences in the metabolism of arsenic compounds. Appl Organomet Chem 8: 175-182, 1994
Buchet JP, Pauwels J, Lauwerys R: Assessment of exposure to inorganic arsenic following ingestion of marine organism by volunteers. Environ Res 66: 44-51, 1994
UNIDO: Summary of report prepared under project no. NC/IND/99/967, New Delhi, 2001
Smith AH, Lingas EO, Rahman M: Contamination of drinking water by arsenic in Bangladesh: A public health emergency. Bull World Health Organ 78: 1093-1103, 2000
Pontius FW, Brown KG, Chen CJ: Health implications of arsenic in drinking water. J Am Water Works Assoc 86: 52-63, 1994
UNIDO: Summary of Report prepared under the Project Concerted Action on Elimination/ Reduction of Arsenic in Ground Water in West Bengal, India, 2001
Mandal BK, Roy Chowdhury T, Samanta J, Basu GK, Chowdhury PP, Chanda CR, Lodh D, Karan NK, Dhar RK, Tamili DK, Das D, Saha KC, Chakraborti D: Arsenic in groundwater in seven districts of West Bengal, India: The biggest arsenic calamity in the world. Curr Sci 70: 976-986, 1996
British Geological Survey: Groundwater Studies for Arsenic Contamination in Bangladesh, Report, 1998
Guha Mazumder DN, Chakraborty AK, Ghose A, Chakraborty DP, Dey SB, Chattopadhyay N: Chronic arsenic toxicity from drinking tubewell water in rural West Bengal. Bull WHO 66: 499-506, 1988
Dhar RK, Biswas BK, Samanta G, Mandal BK, Chakraborti D, Roy S, Jafar A, Islam A, Ara J, Kabir S, Khan AW, Ahmed SA, Hadi SA: Groundwater arsenic calamity in Bangladesh. Curr Sci 73: 48-59, 1997
PHED: Final report National Drinking Water Mission Project on Arsenic Pollution on Groundwater in West Bengal. Steering Committee on Arsenic Investigation, 1993
Roy P, Saha A: Metabolism and toxicity of arsenic: A human carcinogen. Curr Sci 82: 38-45, 2002
Buchet JP, Lauwerys R, Roels H: Comparison of the urinary excretion of arsenic metabolites after a single dose of sodium arsenite, monomethylarsonate or dimethylarsinate in man. Int Arch Occup Environ Health 48: 71-79, 1981
Du Pont O, Ariel I, Warren SL: The distribution of radioactive arsenic in the normal and tumor-bearing (Brown-Pearce) rabbit. Am J Syph Gonorrhea Vener Dis 26: 96-118, 1941
Lin S, Cullen WR, Thomas DJ: Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase. Chem Res Toxicol 12: 924-930, 1999
Doudoroff M, Barker HA, Hassid WZ: Studies with bacterial sucrose phosphorylase III: Arsenolytic decomposition of sucrose and glucose-1-phosphate. J Biol Chem 170: 147-150, 1947
Healy SM, Casarez EA, Ayala-Fierro F, Aposhian HV: Enzymatic methylation of arsenic compounds V. Arsenite methyltransferase activity in tissue of mice. Toxicol Appl Pharmacol 148: 65-70, 1998
EPA. Special report on ingested inorganic arsenic: Skin cancer: Nutritional essentiality. Risk Assessment Forum U.S. Environmental Protection Agency, Washington DC, 124, 1988
Pinto SS, McGill CM: Arsenic trioxide exposure in industry. Ind Med Surg 22: 281-287, 1953
Yamauchi H, Takahashi K, Mashiko M, Saitoh J, Yamamura Y: Intake of different chemical species of dictary arsenic by Japanese and their blood and urinary arsenic levels. Appl Organomet Chem 6: 383-388, 1992
Alauddin M, Chowdhury D, Bhattacharya M, Bibi H, Begum S, Islam MS: Speciation of arsenic metabolic intermediates in human urine by chromatography and flow injection hydride generation atomic absorption spectrometry. In: 4th International Conference on 'Arsenic Contamination of Groundwater in Bangladesh: Cause, Effect and Remedy'. Dhaka, 2002
Pormroy C, Charbonneau SM, McCullough RS, Tam GKH: Human retention studies with 74As. Toxicol Appl Pharmacol 53: 550-556, 1980
Foa V, Colombi A, Maroni M: The speciation of the chemicals forms of arsenic in the biological monitoring of exposure to inorganic arsenic. Sci Total Environ Health, Part B, 1: 199-241, 1984
Vahter M, Marafante E, Dencker L: Metabolism of arsenobetaine in mice, rats and rabbits. Sci Total Environ 30: 197-211, 1983
Guha Mazumder DN, De BK, Santra A, Das Gupta J, Ghose N, Roy BK, Ghosh UC, Saha J, Chatterjee A, Dutta S, Haque R, Smith AH, Chakraborty D, Angle CR, Centeno JA: In: W.R. Chappell, C.O. Abernathy, R.L. Calderon (eds). Chronic Arsenic Toxicity: Epidemiology Natural History and Treatment in Arsenic: Exposure and Health Effects. Chapman and Hall, London, 1999, pp 335-347
Cullen WR, McBride BC, Reglinski J: The reaction of methyl arsenicals with thiols: Some biological implications. J Inorg Biochem 21: 179-193, 1984
McKinney JD: Metabolism and disposition of inorganic arsenic in laboratory animals and humans. Environ Geochem Health 14: 43-48, 1992
Marafante E, Vahter M: The effect of methyltransferase inhibition on the metabolism of (74AS) arsenite in mice and rabbits. Chem Biol Interact 50: 49-57, 1984
Marafante E, Vahter M, Envall J: The role of methylation in the detoxication of arsenate in the rabbit. Chem Biol Interact 56: 225-238, 1985
Styblo M, Yamauchi H, Thomas D: Comparative in-vitro mathylation of trivalent and pentavalent arsenicals. Toxicol Appl Pharmacol 135: 172-178, 1995
Scott N, Hatlelid KM, Mackenzie NE, Carter DE: Reactions of arsenic (III) species with glutathione. Chem Res Toxicol 6: 102-106, 1993
Vahter M, Friberg L, Rahnster B, Nygren A, Nolinder P: Airborne arsenic and urinary excretion of metabolites of inorganic arsenic among smelter workers. Int Arch Occup Environ Health 57: 79-91, 1986
Geubel AP, Mairlot MC, Buchet JP, Lauwerys R: Abnormal methylation capacity in human liver cirrhosis. Int J Clin Pharmacol Res 8: 117-122, 1988
Vahter M, Variation in human metabolism of arsenic: In: W.R. Chappell, C.O. Abernathy, R.L. Calderon (eds). Arsenic Exposure and Health Effects. Elsevier Science Ltd., Oxford, 1999, pp 267-279
Healy SM, Wildfang E, Zakharyan RA, Aposhian HV: Diversity of inorganic arsenite biotransformation. Biol Trace Elem 68: 249-266, 1999
Vahter M, Marafante E, Lindgren A, Dencker L: Tissue distribution and subcellular binding of arsenic in marmoset monkeys after injection of 74 As-arsenite. Arch Toxicol 51: 65-77, 1982
Vahter M, Marafante E: Reduction and binding of arsenate in marmoset monkeys. Arch Toxicol 57: 119-124, 1985
Baudouin C, Charveron M, Tarroux R, Gall Y: Environmental pollutants and skin cancer. Cell Biol Toxicol 18: 341-348, 2002
Saha KC: Melanokeratosis from arsenic contaminated tubewell water. Ind J Dermat 29: 37-46, 1984
Wang CT, Chang WT: Arterial tissue of arsenic, selenium and iron in Blackfoot disease patients. Clin Chem Lab Med 39: 645-648, 2001
Aschengrau A, Zierler S, Cohen A: Quality of community drinking water and water occurrence of spontaneous abortion. Arch Environ Health 44: 283-290, 1989
Gomez-Caminero A, Pankow J, Hopenhayn-Rich C, Ferreccio C, Peralta C, Hertz-Picciotto I: Cardiovascular effects of arsenic during pregnancy in Chilean women. Epidemiology 12: 423, 2001
Ahmad SA, Sayed SU, Barua S, Khan MH, Jalil A, Hadi SA, Talukder HK: Arsenic in drinking water and pregnancy outcomes. Environ Health Perspect 109: 629-631, 2001
Byrne AR, Kosta L, Dermejl M, Tusek-Znidaric M: Aspects of some trace elements in human milk. In: P. Bratter, P. Schramel (eds). Trace Element Analytical Chemistry in Medicine and Biology, Vol. 2. Walter de Gruyter, Berlin, 1983, pp 22-35
Concha G, Vogler G, Nermell B, Vahter M: Low-level arsenic excretion in breast milk of native Andean women exposed to high levels of arsenic in the drinking water. Int Arch Occ Environ Health 71: 42-46, 1998
Krachler M, Prohaska T, Koellensperger G, Rossipal E, Stingeder G: Concentrations of selected trace elements in human milk and in infant formulas determined by magnetic sector field inductively coupled plasma-mass spectrometry. Biol Trace Elem Res 76: 97-112, 2000
Grandjean P, Weihe P, Needham LL, Burse VW, Patterson DG, Sampson EJ, Jogersen PJ, Vahter M: Relation of a seafood diet to mercury, selenium, arsenic and PCB and other organochlorine concentrations in human milk. Environ Res 71: 29-38, 1995
Rudel R, Slayton TM, Beck BD: Implications of arsenic genotoxicity for dose response of carcinogenic effects. Reg Toxicol Pharmacol 23: 87-105, 1996
Yih LH, Ho IC, Lee TC: Sodium arsenite disturbs mitosis and induces chromosome loss in human fibroblasts. Cancer Res 57: 5051-5059, 1997
Liao KH, Gustafson DL, Fox MH, Chubb LS, Reardon KF, Yang RSH: A biologically based model of growth and senescence of Syrian hamster embryo (SHE) cells after exposure to arsenic. Environ Health Perspect 109: 1207-1213, 2001
Huang SC, Huang CYF, Lee TC: Induction of mitosis-mediated apoptosis by sodium arsenite in HeLaS3 cells. Biochem Pharmacol 60: 771-780, 2000
Huang RN, Lee TC: Cellular uptake of trivalent arsenite and pentavalent arsenate in KB cells cultured in phosphate free medium. Toxicol Appl Pharmacol 136: 243-249, 1996
Mass MJ, Tennant A, Roop BC, Cullen WR, Styblo M, Thomas DJ, Kligerman AD: Methylated trivalent arsenic species are genotoxic. Chem Res Toxicol 14: 355-361, 2001
Baudouin C, Charveron M, Tarroux R, Gall Y: Environmental pollutants and skin cancer. Cell Biol Toxicol 18: 341-348, 2002
Park JY, Rim JH, Choe YB, Youn JI: Arsenic keratosis and pigmentation accompanied by multiple Bowen's disease and genitourinary cancer in a psoriasis patient. J Dermatol 29: 446-451, 2002
Bernstam L, Lan CH, Lee J, Nriagu JO: Effects of arsenic on human keratinocytes: Morphological, physiological, and precursor incorporating studies. Environ Res 89: 220-235, 2002
Guo HR, Yu HS, Hu H, Monson RR: Arsenic in drinking water and skin cancers: Cell-type specificity (Taiwan, ROC). Cancer Causes & Control 12: 909-916, 2001
Welch AH, Westjohn DB, Helsel DR, Wanty RB: Ground Water 38: 589-604, 2000
USEPA Drinking Water Regulations and Health Advisories (EPA822-B-96-002): Washington, DC, 1996
USEPA. National Primary Drinking Water Regulations: Arsenic and Clarifications to Compliance and New Source Contaminants Monitoring. Final Rule. Federal Register, Part VIII. Environmental Protection Agency. 66: 6976-7066, 2001
Bhattacharyya R, Jana J, Nath B, Sahu SJ, Chatterjee D, Jacks G: Groundwater arsenic mobilization in the Bengal Delta Plain and Ferralite, the possible remedial measure — a case study. Appl Geochem 18: 1435-1451, 2003
Uthus EO: Arsenic deprivation in rats is affected by vitamin B12 status. Faseb J 16: A270-A270, 2002
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Bhattacharyya, R., Chatterjee, D., Nath, B. et al. High arsenic groundwater: Mobilization, metabolism and mitigation – an overview in the Bengal Delta Plain. Mol Cell Biochem 253, 347–355 (2003). https://doi.org/10.1023/A:1026001024578
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DOI: https://doi.org/10.1023/A:1026001024578