Abstract
The preparation of 188Re-glucoheptonate (GH) is described using 188Re, which was obtained from an alumina based 188W/188Re generator. The dependence of the radiolabeling yields of 188Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-GH was ~99%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of 188Re-GH was carried out in rats and compared to the biological behavior of 99mTc-GH.
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Pervez, S., Mushtaq, A., Arif, M. et al. 188Rhenium-glucoheptonate: A radiopharmaceutical for intravascular radiation therapy. Journal of Radioanalytical and Nuclear Chemistry 256, 293–296 (2003). https://doi.org/10.1023/A:1023945603430
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DOI: https://doi.org/10.1023/A:1023945603430