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Cystatin C and Cysteine Proteinases during the Development and Therapy of Lewis Lung Adenocarcinoma in Mice

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Abstract

We measured plasma cystatin C concentration and activity of cathepsins B and L in tumor tissue as possible markers for the efficiency of antitumor therapy and prognostic criteria for Lewis lung adenocarcinoma in mice. Plasma cystatin C concentration markedly decreased in mice with tumors. During successive therapy the increase in plasma cystatin C concentration correlated with the degree of inhibition of tumor growth. Activities of cathepsins B and L in the liver increased in animals with tumors. In mice receiving successive antitumor therapy activities of cathepsins B and L increased in tumor tissue, but decreased in the liver (compared to untreated animals).

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Authors and Affiliations

  1. Siberian Division of the Russian Academy of Medical Sciences, Institute of Physiology, Novosibirsk

    T. A. Usova, O. N. Poteryaeva, S. Ya. Zhanayeva, E. S. Yarygina & T. A. Korolenko

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  1. T. A. Usova
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  2. O. N. Poteryaeva
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  3. S. Ya. Zhanayeva
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  4. E. S. Yarygina
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  5. T. A. Korolenko
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Usova, T.A., Poteryaeva, O.N., Zhanayeva, S.Y. et al. Cystatin C and Cysteine Proteinases during the Development and Therapy of Lewis Lung Adenocarcinoma in Mice. Bulletin of Experimental Biology and Medicine 135, 81–84 (2003). https://doi.org/10.1023/A:1023462316317

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  • DOI: https://doi.org/10.1023/A:1023462316317

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